Yerasimides, T. G.; Margolis, G.; Ponton, H. J.
August 1963
Angiology;Aug1963, Vol. 14 Issue 8, p394
Academic Journal
The protective action of various agents against the severe anatomic injury to the canine spinal cord resulting from the retrograde injection of the contrast material, Na acetrizoate 70 per cent, has been studied. Excellent protection was afforded by a series of vasodepressor agents, including trimethaphan camphorsulfate (Arfonad), papaverine HCl, procaine HCl, and carbocaine HCl. The vasopressor agent, levarterenol, exerted no protective action. The protective agents were effective when administered prophylacticaUy, immediately before the Na acetrizoate, but were completely ineffective when administered after the contrast medium. In these studies a lack of correlation was observed between protective actions against convulsive reactions and against anatomic injury.


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