Mark, Morton F.; Imparato, Anthony M.; Hutner, S. H.; Baker, Herman
August 1963
Angiology;Aug1963, Vol. 14 Issue 8, p383
Academic Journal
The relative toxicity of seven radiopaque agents presently used in angiography was determined, with the ciliate protozoan Tetrahymena pyriformis as the test organism. In the first group of experiments, the contrast agents selected were those for which adequate studies in higher animals were available for comparison. In the final studies the relative toxicity of two new compounds, methylglucamine methalamate and sodium methalamate, was determined. Forty-eight-hour cultures of the ciliate were suspended in 0.5 N saline solution and were exposed to varying concentrations of the radiopaque agents. The index of toxicity was reduction in motility, estimated by direct microscopic observation. The results indicated that of the older compounds, sodium diatrizoate and methylglucamine diatrizoate are the least toxic, sodium acetrizoate the most toxic, and sodium diprotrizoate and iodopyracet, intermediate. For the new agents, the results with this method indicate that methylglucamine methalamate is somewhat less toxic than the diatrizoates, and the toxicity of sodium methalamate is of the same order as that for iodopyracet.


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