Waterbury, Larry S.; Hampton, James W.
April 1967
Angiology;Apr1967, Vol. 18 Issue 4, p197
Academic Journal
A case is presented of an elderly man who developed migrating thrombophlebitis prior to the discover of a primary carcinoma of the cecum with hepatic metastases. The clinical �hypercoagulable state� paralleled in vitro studies that indicated accelerated clotting. The mixing of the patient's whole blood with the whole blood of a healthy and compatible individual shortened the clotting time of the individual to that of the patient. Although the prothrombin time was prolonged by the administration of anticoagulants, there was demonstrated an increase in Factor IX (Christmas factor) activity. Increased Factor IX activity implicates the initiator factors in the mechanism of intravascular thrombosis.


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