TITLE

CLINICAL EVALUATION OF CHLORISONDAMINE (ECOLID) IN THE TREATMENT OF HYPERTENSION

AUTHOR(S)
Kert, Morley J.; Nordyke, Robert A.; Shickman, Martin D.; Weatherby Jr., Harold R.; Mailman, Richard H.; Franz, Gregory E.; Penzelle, Yale; Allen Smith, L.
PUB. DATE
October 1958
SOURCE
Angiology;Oct1958, Vol. 9 Issue 5, p303
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Ecolid, a potent ganglionic blocking agent, was administered to a group of outpatients attending a hypertension clinic. Twenty-eight of these patients with severe hypertension were followed 1 to 13 months. Almost 40 per cent experienced significant decreases in blood pressure, and in over half of these the response was considered good. A 12-hour dosage schedule of Ecolid proved satisfactory. Undesirable side effects occurred in 71 per cent of the group but were mild in most instances. For this reason, Ecolid would appear to be indicated chiefly in patients with severe hypertension. Orthostatic hypotension with syncope, the most serious side effect, can be prevented by careful titration of dosage and administration of the medication after the morning and evening meals. In this respect, a small starting dose of 10 or 12.5 mg is desirable. Careful supervision and instruction of the patient is essential for successful therapy of hypertension with Ecolid.
ACCESSION #
16400198

 

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