TITLE

EFFECTS OF TOPICALLY APPLIED EPINEPHRINE, NOREPINEPHRINE, ACETYLCHOLINE AND HISTAMINE ON THE INTERMEDIATE CIRCULATION OF THE MOUSE SPLEEN

AUTHOR(S)
Fleming, William W.; Parpart, Arthur K.
PUB. DATE
October 1958
SOURCE
Angiology;Oct1958, Vol. 9 Issue 5, p294
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
1. Epinephrine, acetylcholine, norepinephrine and histamine, in that order of potency, all constrict the terminal arterioles in the spleen. Larger arterial vessels were observed to constrict only to epinephrine and norepinephrine. 2. The threshold sensitivity of epinephrine, norepinephrine and acetylcholine increases with time. The relation of histamine sensitivity to time was not investigated due to technical difficulties. 3. The rising sensitivity was found not to be related to shock, urethane anesthesia, the presence or absence of protein in the solution or the repeated application of the drug. 4. Dibenamine strongly inhibits the action of both epinephrine and norepinephrine on splenic vessels and may actually reverse the effect of epinephrine to one of dilation. The blocking activity of dibenamine is only slowly reversible. 5. The constricting effect of acetylcholine is moderately potentiated by Eserine and strongly inhibited by atropine. Hexamethonium is incapable of inhibiting acetylcholine action on splenic arterioles. 6. The findings on inhibitors are presented as evidence that the activity of acetylcholine on splenic vessels is muscarinic, not nicotinic, acting directly on the vascular smooth muscle. 7. The sensitivity of terminal arterioles to a dose of norephinephrine or histamine is diminished by a previous administration of the same drug. No such desensitization was observed with epinephrine or acetylcholine.
ACCESSION #
16400189

 

Related Articles

  • FACTORS AFFECTING ARTERIAL BLOOD FLOW AND ITS MEASUREMENT. Barcroft, Henry // Angiology;Jul1966, Vol. 17 Issue 7, p443 

    Discusses factors affecting arterial blood flow and its measurement. Action of adrenaline on the blood vessels in human muscle; Methods of examining blood flow in muscle and skin; Investigation of the action of other substances on the circulation in the human limb.

  • Improvement of parenchymal and vascular enhancement using saline flush and power injection for multiple-detector-row abdominal CT. Schoellnast, Helmut; Tillich, Manfred; Deutschmann, Hannes A.; Stessel, Uwe; Deutschmann, Michael J.; Schaffler, Gottfried J.; Schoellnast, Renate; Uggowitzer, Martin M. // European Radiology;Apr2004, Vol. 14 Issue 4, p659 

    The aim of this study was to determine if a saline solution flush following low dose contrast material bolus improves parenchymal and vascular enhancement during abdominal multiple detector-row computed tomography (MDCT). Forty-one patients (24 men and 17 women; mean age 49 years, age range...

  • AMBULATORY USE OF SYMPATHETIC NERVE BLOCKS: PRESENT DAY CLINICAL INDICATIONS. Rickles, Julian A. // Angiology;Jun1977, Vol. 28 Issue 6, p394 

    Discusses the important physiologic facts related to sympathetic nerve function. Presence of multiple systemic physical and emotional symptoms that can be out of proportion to the injury or the disease process; Contraction of the blood vessels by normal sympathetic tone; Release of adrenalin and...

  • Splenic Artery Aneurysm and Upper Gastrointestinal Bleeding in a Nulliparous Woman. Huncharek, Michael; Klassen, Henry; Klassen, Mary // Angiology;Aug1994, Vol. 45 Issue 8, p733 

    An eighty-three-year-old nulliparous woman hospitalized for orthopedic surgery developed postoperative upper gastrointestinal bleeding and hypotension resulting in her death. Postmortem examination revealed a ruptured splenic artery aneurysm. This is the second reported case of gastrointestinal...

  • THE MICROCIRCULATION OF THE SPLEEN OF THE MOUSE. Parpart, Arthur K.; Whipple, Allen O.; Chang, Joseph J. // Angiology;Aug1955, Vol. 6 Issue 4, p350 

    Focuses on the fundamental problems of anatomy, physiology, defense reactions, and pathology presented by the living spleen. Significance of trying to understand how blood circulates through the spleen; Contention of the researchers that any complete description of the structure and functioning...

  • THE COMPARATIVE SENSITIVITY OF ISOLATED CORONARY AND. SYSTEMIC VESSELS TO VASOMOTOR AGENTS. Oppelt, W. W.; Ederstrom, H. E. // Angiology;Jun1959, Vol. 10 Issue 3, p153 

    Coronary and sytemic arteries and veins were removed from fresh beef and dog hearts and prepared in the form of strips for studies in vitro. Strips from systemic arteries and vein, contracted with epinephrine and norepinephrine, whereas those from coronary arteries relaxed. Coronary vein strips...

  • DIRECT TENSION RECORDING FROM SMOOTH MUSCLE OF RESISTANCE VESSELS FROM VARIOUS ORGANS. Bohr, David F.; Goulet, Patricia L.; Taquini, Alberto C. // Angiology;Oct1961, Vol. 12 Issue 10, p478 

    A method is described for the preparation of smooth muscle strips from resistance vessels 200 to 300 � in diameter. Contractions were recorded when such preparations were stimulated by various physiologically vasocative agents. Individuality of the responses of smooth muscle obtained from...

  • Epinephrine, norepinephrine and dopamine infusions decrease propofol concentrations during continuous propofol infusion in an ovine model. Myburgh, John A.; Upton, Richard N.; Grant, Cliff; Martinez, Allison // Intensive Care Medicine;Jan2001, Vol. 27 Issue 1, p276 

    Objective: To determine the effects of exogenous ramped infusions of epinephrine, norepinephrine and dopamine on arterial and effluent brain blood concentrations of propofol under steady state intravenous anesthesia. Design: Prospective, randomized animal study. Setting: University research...

  • Sepsis causes presynaptic histamine H3 and a2-adrenergic dysfunction in canine myocardium. Cheng, Zao-Qin; Bose, Deepak; Jacobs, Han; Bruce Light, R.; Mink, Steven N. // Cardiovascular Research;Nov2002, Vol. 56 Issue 2, p225 

    Objective: Histamine H3 receptors and a2-adrenoceptors are presynaptic receptors that modulate norepinephrine (NE) release from sympathetic nerves innervating the cardiovascular system. We previously showed that cardiac H3 receptors are activated in sepsis, and that this activation leads...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics