TITLE

UPTAKE AND BREAKDOWN OF CATECHOLAMINES IN VASCULAR TISSUE

AUTHOR(S)
Raab, W.; Gigee, W.
PUB. DATE
October 1958
SOURCE
Angiology;Oct1958, Vol. 9 Issue 5, p283
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Chemical determination of total catecholamines and bioassay of epinephrine and norepinephrine, respectively, in the aorta, renal arteries and vena cava inferior of the dog revealed the presence of relatively high concentrations of these compounds in vascular tissue. The catecholamine content of the vena cava inferior above the entry of the adrenal veins was about twice as high as that of the distal portion which is not contaminated by blood from the adrenal medulla. Intravenous infusion of epinephrine within the physiologic range caused irregular augmentations of the total vascular catecholamine content. Intraperitoneal injection of massive doses of both epinephrine and norepinephrine was followed by large increases of the catecholamine concentration in vascular tissue, both colorimetrically and by bioassay. When oxygenated Ringer solution or heparinized blood with added epinephrine was circulated through the lumen of isolated aortas in vitro, considerable amounts of epinephrine disappeared from the perfusatea, apparently due to absorption by the aortic tissue. However, only fractions of that epinephrine deficit could be recovered from the aortic wall. Tissue norepinephrine was simultaneously augmented (demethylated deposited epinephrine?.) It is concluded that vascular tissue (in analogy to that of the heart muscle) avidly absorbs epinephrine and norepinephrine from the circulating blood and metabolizes them rapidly whereby a certain amount of pharmacodynamically inactive catechol derivatives accumulate temporarily. Only after administration of massive doses of epineplirine and norepinephrine does their apparent breakdown lag behind the speed of absorption, and large quantities can be demonstrated in the tissue. The presumable significance of local catecholamine action and turnover in vascular tissue for the process of atherogenesis is briefly reviewed.
ACCESSION #
16400167

 

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