Rubin, Wallace; Anderson, Jack R.
October 1958
Angiology;Oct1958, Vol. 9 Issue 5, p256
Academic Journal
Many patients with clinical disease entities involving the inner ear present themselves with symptoms of disturbance in balance, ringing in the ear and sudden or gradual impairment of hearing. These symptoms may be explained on the basis of labyrinthine artery insufficiency. This circulatory embarrassment in the inner ear can result from either spasm or complete obstruction of the labyrinthine vessels. Presumably an agent capable of increasing blood flow through these vessels should produce improvement in vestibular and auditory function. The peripheral vasodilator, nylidrin hydrochloride, is known to increase central retinal artery blood flow. This action suggested its potential therapeutic value in labyrinthine arterial insufficiency. In a limited number of cases, carefully evaluated by complete physician examination and audiologic workup, nylidrin hydrochloride was found to be superior to all other vasodilating measures in its effect on the labyrinthine arteries. This vasodilator could be used not only as an effective therapeutic agent in circulatory disorders of the inner ear, but as a convenient diagnostic tool in the assessment of vestibular and auditory problems.


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