Shapiro, Shepard
April 1959
Angiology;Apr1959, Vol. 10 Issue 2, p126
Academic Journal
No one form of therapy can be expected to correct the multiple factors operating in coronary arteriosclerosis. Proper treatment requires agents to minimize changes in the vascular walls by preventing atheromatous deposits, to minimize emotional stress and restore the retarded blood flow and to make the blood less coagulable. The results herein described indicate that angina pectoris and coronary insufficiency can be favorably influenced by the use of pentaerythritol tetranitrate and a tranquilizer, meprobamate. The addition of anticoagulant therapy to the above medication yielded the most favorable results in a small group of 19 patients recently recovered from acute myocardial infarction. In 12 patients with elevated serum total cholesterol values, suggestive improvement followed the use of concentrates of essential unsaturated fatty acids, in addition to PISTN and meprobamate. The results have been sufficiently encouraging to warrant pursuing this investigation further in a larger series of patients and to suggest that we may be close to a more satisfactory therapeutic, or even prophylactic, method of treating coronary artery disorders related to arteriosclerosis.


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