Clinical Relevance of Intrinsic Sympathomimetic Activity of Beta Blockers Used in Angina

Kostis, J. B.; DeFelice, E. A.; Frishman, W.; Hosier, M.; Krieger, S. K.; Aglitz, N.; Kuo, P. T.
November 1981
Angiology;Nov1981, Vol. 32 Issue 11, p780
Academic Journal
β-blockers are effective in the symptomatic relief of angina pectoris by decreasing myocardial oxygen demand during effort and emotional stress. Agents with ISA such as pindolol produce effective β-blockade during effort or emotional stress while conferring significant protection from myocardial depression and bradycardia at rest. In addition, agents with ISA have been shown to depress respiratory function to a lesser extent and to induce fewer peripheral vascular side effects than compounds devoid of this property. These potential effects of ISA may be counterbalanced by the consideration that ISA may be undesirable in angina occurring at rest or at low exercise levels. Additional well-controlled trials in patients with angina and resting bradycardia or impaired left ventricular function are needed to further document the clinical importance of ISA.


Related Articles

  • Angilol.  // Royal Society of Medicine: Medicines;2002, p61 

    The article provides information on Angilol, a proprietary, prescription-only preparation of the beta-blocker propranolol hydrochloride. It can be used as an antihypertensive for raised blood pressure, as an anti-angina treatment to relieve symptoms and to improve exercise tolerance and as an...

  • An Ongoing Debate: Should Beta Blockers Be Used for Primary Hypertension? Howard, Patricia A. // Hospital Pharmacy;Jan2007, Vol. 42 Issue 1, p22 

    The article focuses on the findings of several studies regarding the use of beta blockers in the treatment of primary hypertension (HTN). Research conducted by the British National Institute of Health and Clinical Evidence (NICE) found a higher risk of myocardial infarction (MI) with beta...

  • Beta-blocker efficacy dependent on genes.  // GP: General Practitioner;10/7/2005, p4 

    The article reports that researchers in the U.S. have found that how long a patient taking beta-blockers for an acute coronary syndrome will survive is largely determined by their genes. They looked at variations in the beta-adrenergic receptor genes in 597 patients who were treated with...

  • Reports of diarrhoea with carvedilol.  // WHO Drug Information;2004, Vol. 18 Issue 3, p217 

    The article reports on cases of diarrhoea with the use of carvedilol. Carvedilol is a non-cardioselective beta-blocker with alpha blocking activity. It is indicated for the management of essential hypertension, angina pectoris and as adjunctive therapy in chronic heart failure. Diarrhoea is a...

  • Apical Hypokinesis in a Patient with Hypertrophic Cardiomyopathy and Myocardial Bridging: Reversal with Beta-Blockade. Rentoukas, Elias L.; Deftereos, Spiros G.; Alpert, Martin A.; Nikas, Dimitris J.; Lazaros, George A.; Petropoulou, Evdokia N.; Zacharoulis, Apostolos A. // Angiology;May1999, Vol. 50 Issue 5, p409 

    A 42-year-old man presented with effort angina pectoris of 20 minutes' duration. Hypertrophic obstructive cardiomyopathy, severe myocardial bridging involving the midleft anterior descending coronary artery, and apical hypokinesis were identified. Regional wall motion normalized following the...

  • Study: Inexpensive Four-Drug Combo Saves Heart Patients' Lives; 90 Percent Cut in Death Risk From Aspirin, Beta Blocker, ACE Inhibitor, Statin.  // Ascribe Newswire: Medicine;2/19/2004, p8 

    This article reports that heart attack and unstable angina patients who were prescribed all four types of proven medications had a 90 percent lower risk of dying in the six months after they left the hospital than those who received none of the drugs. The four classes of medications are:...

  • The Beneficial Effect of the Beta Blocker Timolol In Stable Angina Pectoris. Di Segni, Elio; Fidelman, Eva; David, Daniel; Klein, Herman O.; Kaplinsky, Elieser // Angiology;Apr1980, Vol. 31 Issue 4, p238 

    Timolol is a new beta blocker with cardioselective properties. A single blind controlled study was performed to assess the efficacy of timolol maleate in doses of 10 to 30 mg per day in 20 patients affected by stable angina pectoris. The patients received a placebo for a baseline period of 2...

  • Solvent-FreeMicrowave Synthesis of Aryloxypropanolamines by Ring Opening of Aryloxy Epoxides. Kureshy, Rukhsana I.; Ahmad, Irshad; Pathak, Kavita; Khan, N. H.; Abdi, Sayed H. R.; Bajaj, H. C.; Suresh, Eringathodi // Organic Chemistry International;2009, p1 

    The ring opening reaction of aryloxyepoxides with isopropylamine under solvent-free microwave irradiation produced therapeutically useful β-blockers-aryloxypropanolamines in excellent yield (up to 98%) in 10 minutes which is considerably less than the time taken in classical heating (∼16...

  • The Use of Beta-Adrenergic Blockers in the Treatment of Angina and Hypertension. Caris, Timothy N. // Angiology;Mar1986 Part 2, Vol. 37 Issue 3, p215 

    During the past decade, beta-adrenoreceptor blocking agents have proved to be valuable assets in our therapeutic armamentarium for management of both angina pectoris and essential hypertension. In ischemic heart disease, these agents reduce myocardial oxygen requirements by decreasing the force...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics