TITLE

HEMORHEOLOGICAL FACTORS IN RAYNAUD'S PHENOMENON

AUTHOR(S)
Dintenfass, L.
PUB. DATE
July 1977
SOURCE
Angiology;Jul1977, Vol. 28 Issue 7, p472
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A study of blood viscosity, plasma viscosity, aggregation of red cells, rigidity of red cells, apparent viscosity of artificial thrombi in vitro, and albumin/fibrinogen and albumin/globulin ratios in patients exhibiting Raynaud's phenomenon showed that nearly all patients have abnormal hemorheologic or protein factors. Different groups of patients show different abnormalities. Individual patients exhibit from one to ten abnormal factors. The most common abnormalities are increased aggregation of red cells and increased rigidity of red cell; although abnormalities of albumin/fibrinogen and albumin/globulin ratios are common. When the patients' data are compared with known normal values for hemorheologic and protein factors, there very significant differences in the following factors: plasma viscosity (elevated in patients, P < 0.005), albumin/globulin ratio (decreased in patients, P < 0.0005), globulin level (elevated in patients, P < 0.0025) albumin/fibrinogen ratio (decreased in patients, P < 0.025), etc. Although the viscosity of whole blood is not a common feature of all patients, a hyperviscosity syndrome exists nevertheless 30 either through increased plasma viscosity, increased aggregation of red cells, or increased rigidity of red cells.
ACCESSION #
16398245

 

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