Evaluation of Buflomedil in Geriatric Patients Suffering from Vascular Cerebral Insufficiency

Demichelis Genesio, Miguel Angel; Sanz, Milagros Cid
October 1981
Angiology;Oct1981, Vol. 32 Issue 10, p717
Academic Journal
Buflomedil is a vasoactive substance, with good patient tolerance, similar in its effects to those obtained with the derivatives of rye ergot and lacking undesirable side effects. But its activity in the CVCI of the aged subject, both in its clinical-neurologic component and in the psychiatric one, is shown to be superior; it opens up a new path in the treatment of this disease which is so widespread and invalidating, and it signifies a real therapeutic contribution and opens up new prospects for the immediate future. We do not know the intimate details of its action mechanism, but we are in a position to assure that it does not produce hemodynamic modifications in the main circulation, and it is very probable that its benefits are shown at the microcirculation complex level. Since it did not figure in our plan of work from the start nor did we count on the technical means necessary, the possible modifications which buflomedil produces on the rheologic factors were not studied, but we do not have any doubt at all that it has a clear activity, shown by the significant variations found at coagulation lysis level and thromboplastin time. On this supposition, buflomedil would combine the benefits expected of a vasoactive substance, together with those which we have been able to appreciate and record in patients treated with anti-platelet-aggregating drugs. All the investigation protocols and the results obtained in the parametric, biochemical testification, and evaluative tabulation, are at the disposal of those who require amplification.


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