TITLE

MEASUREMENT OF INTRAHEPATIC SHUNTED BLOOD FLOW BY MEANS OF HEAT-DENATURED RADIOIODINATED SERUM ALBUMIN IN EXPERIMENTAL HEPATIC INJURIES

AUTHOR(S)
Nakamura, Takashi; Nakamura, Shozo; Suzuki, Osamu; Aikawa, Tatsuya; Onodera, Atsushi; Iida, Hiroyoshi
PUB. DATE
October 1969
SOURCE
Angiology;Oct1969, Vol. 20 Issue 9, p502
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Heat-denatured radioiodinated human serum albumin which was phagocytized by the reticuloendothelial system (finely aggregated albumin) was injected into the portal vein or into the hepatic artery of rats, and the percentage of intrahepatic shunt was calculated from the radioactivity of the resected liver and that of injected solution. The percentage of intrahepatic shunt increased slightly in hepatic fibrosis and markedly in hepatic cirrhosis. In hepatic carcinoma produced by feeding 3'-methyldimethylaminoazobenzene, no definite increase was observed. The percentage of intrahepatic shunt was slightly higher in the group injected via the arterial route than in the group via the portal route. After the measurement of percentage of intrahepatic shunt, the hepatic vessels of the rats were morphologically studied by means of dye injection. The intrahepatic shunts between the hepatic arteries and the hepatic veins and between the portal veins and the hepatic veins were always found in hepatic cirrhosis, and occasionally found in fibrosis. The percentage of intrahepatic shunt was parallel to that of morphologically demonstrated intrahepatic shunts. Coarsely aggregated albumin was found to be inadequate for the measurement of the intrahepatic shunted blood flow.
ACCESSION #
16397181

 

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