Double-Blind Clinical and Plethysmographic Study of Calcium Dobesilate in Patients with Peripheral Microvascular Disorders

Hachen, H. J.; Lorenz, P.
July 1982
Angiology;Jul1982, Vol. 33 Issue 7, p480
Academic Journal
The article presents information on the double-blind clinical and plethysmographic study of calcium dobesilate in patients with peripheral microvascular disorders. In Central Europe approximately 20% of the adult population above the age of thirty shows symptoms and signs of chronic venous insufficiency (CVI). The pathophysiology of CVI is directly related to the severe hemodynamic changes that gradually develop as the valvular system of the superficial and perforating veins becomes incompetent. The study confirms that calcium dobesilate significantly reduces the intensity of heaviness, pressure and edema in the lower extremities in patients with signs of venous valvular incompetency and venous hypertension. The remarkable subjective improvement reported by the patients correlates well with the correction of MVI, MVO and CF as determined with strain-gauge plethysmography.


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