Shapiro, Shepard
February 1961
Angiology;Feb1961, Vol. 12 Issue 2, p53
Academic Journal
Angina pectoris occurs when the oxygen supply to the myocardium falls below the physiologic requirement of the moment. This anoxia is reversible and when the oxygen supply becomes adequate the angina attack subsides. These attacks can be prevented or controlled by coronary vasodilator drugs. The drug described in this study, isosorbide dinitrate, has been effective in about three-fourths of 51 patients with severe angina. Thirty-nine of the patients experienced either disappearance of the pain symptom or substantial reduction in frequency and duration of attacks. In view of the fact that the angina attacks were uniformly severe in this group of patients, in my opinion, the consistency and degree of response to isosorbide dinitrate therapy was satisfactory.


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