TITLE

Management of Arrhythmias with ''Calcium Antagonists''

AUTHOR(S)
Zipes, Douglas P.; Gilmour Jr., Robert F.
PUB. DATE
August 1982
SOURCE
Angiology;Aug1982, Vol. 33 Issue 8, p540
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article focuses on management of arrhythmias with ''calcium antagonists." Cardiac electrophysiologists, assuming that exclusively sodium and potassium movements were involved, applied the Hodgkin-Huxley analysis of transmembrane current flow to explain the considerably more complex waveforms of cardiac action potentials. Scientists noted that the overshoot of the ventricular action potential was rather insensitive to the extracellular sodium concentration, and in the early l960s many investigators working independently showed that the kinetics of the inward ionic flow in cardiac fibers could not be satisfactorily described in terms of sodium ion movement alone.
ACCESSION #
16395589

 

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