Management of Arrhythmias with ''Calcium Antagonists''

Zipes, Douglas P.; Gilmour Jr., Robert F.
August 1982
Angiology;Aug1982, Vol. 33 Issue 8, p540
Academic Journal
The article focuses on management of arrhythmias with ''calcium antagonists." Cardiac electrophysiologists, assuming that exclusively sodium and potassium movements were involved, applied the Hodgkin-Huxley analysis of transmembrane current flow to explain the considerably more complex waveforms of cardiac action potentials. Scientists noted that the overshoot of the ventricular action potential was rather insensitive to the extracellular sodium concentration, and in the early l960s many investigators working independently showed that the kinetics of the inward ionic flow in cardiac fibers could not be satisfactorily described in terms of sodium ion movement alone.


Related Articles

  • MicroRNAs and Cardiac Conduction. Latronico, M. V. G.; Condorelli, G. // Current Drug Targets;Aug2010, Vol. 11 Issue 8, p907 

    No abstract available.

  • Powerful Technique to Test Selectivity of Agents Acting on Cardiac Ion Channels: The Action Potential Voltage-Clamp. Szentandr�ssy, N.; Nagy, D.; Ruzsnavszky, F.; Harmati, G.; B�ny�sz, T.; Magyar, J.; Szentmikl�si, A. J.; N�n�si, P. P. // Current Medicinal Chemistry;Aug2011, Vol. 18 Issue 24, p3737 

    Action potential voltage-clamp (APVC) is a technique to visualize the profile of various currents during the cardiac action potential. This review summarizes potential applications and limitations of APVC, the properties of the most important ion currents in nodal, atrial, and ventricular...

  • Dispersion of cardiac action potential duration and the initiation of re-entry: A computational study. Clayton, Richard H; Holden, Arun V // BioMedical Engineering OnLine;2005, Vol. 4, p11 

    Background: The initiation of re-entrant cardiac arrhythmias is associated with increased dispersion of repolarisation, but the details are difficult to investigate either experimentally or clinically. We used a computational model of cardiac tissue to study systematically the association...

  • Spatial heterogeneity of myocardial perfusion predicts local potassium channel expression and action potential duration. Stoll, Marion; Quentin, Michael; Molojavyi, Andrej; Thämer, Volker; Decking, Ulrich K. M. // Cardiovascular Research;Feb2008, Vol. 77 Issue 3, p489 

    Aims: In the heart, there is not only a transmural gradient of left ventricular perfusion and action potential duration (APD), but also spatial heterogeneity within each myocardial layer, where local blood flow and energy turnover vary more than three-fold between individual regions. We analysed...

  • Seasonal acclimatization of the cardiac action potential in the Arctic navaga cod ( Eleginus navaga, Gadidae). Hassinen, Minna; Abramochkin, Denis; Vornanen, Matti // Journal of Comparative Physiology B: Biochemical, Systemic & Env;Apr2014, Vol. 184 Issue 3, p319 

    Freshwater fishes of north-temperate latitudes adjust electrical excitability of the heart to seasonal temperature changes by changing expression levels of ion channel isoforms. However, little is known about thermal responses of action potential (AP) in the hearts of marine polar fishes. To...

  • Efficient and specific cardiac IK1 inhibition by a new pentamidine analogue. Takanari, Hiroki; Nalos, Lukas; Stary-Weinzinger, Anna; de Git, Kathy C.G.; Varkevisser, Rosanne; Linder, Tobias; Houtman, Marien J.C.; Peschar, Maaike; de Boer, Teun P.; Tidwell, Richard R.; Rook, Martin B.; Vos, Marc A.; van der Heyden, Marcel A.G. // Cardiovascular Research;Jul2013, Vol. 99 Issue 1, p203 

    Aims In excitable cells, KIR2.x ion-channel-carried inward rectifier current (IK1) is thought to set the negative and stable resting membrane potential, and contributes to action potential repolarization. Loss- or gain-of-function mutations correlate with cardiac arrhythmias and pathological...

  • Atria are More Sensitive Than Ventricles to GS-458967-Induced Inhibition of Late Sodium Current. Burashnikov, Alexander; Di Diego, José M.; Goodrow, Robert J.; Belardinelli, Luiz; Antzelevitch, Charles // Journal of Cardiovascular Pharmacology & Therapeutics;Sep2015, Vol. 20 Issue 5, p501 

    Introduction: The differential response of atrial and ventricular cells to late sodium channel current (late INa) inhibition has not been thoroughly investigated. The aim of the present study was to compare the atrioventricular differences in electrophysiological actions of GS-458967, a potent...

  • Effects of the Ionic Composition of the External Medium on Blockade of the Ion Channels of AMPA Receptors. Tikhonova, T.; Magazanik, L.; Tikhonov, D. // Neuroscience & Behavioral Physiology;Jul2011, Vol. 41 Issue 6, p647 

    The ionic composition of the medium can influence the actions of many pharmacological agents. We report here our studies of the effects of the extracellular sodium concentration on blockade of calcium-permeable ion channels of AMPA receptors by the cationic phenylcyclohexyl derivative IEM-1925....

  • The Regulation of Glucose-Excited Neurons in the Hypothalamic Arcuate Nucleus by Glucose and Feeding-Relevant Peptides. Wang, R.; Liu, X.; Hentges, S. T.; Dunn-Meynell, A. A.; Levin, B. E.; Wang, W.; Routh, V. H. // Diabetes;Aug2004, Vol. 53 Issue 8, p1959 

    Glucosensing neurons in the hypothalamic arcuate nucleus (ARC) were studied using electrophysiological and immunocytochemical techniques in neonatal male Sprague-Dawley rats. We identified glucose-excited and -inhibited neurons, which increase and decrease, respectively, their action potential...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics