Baugh, James E.
January 1963
Angiology;Jan1963, Vol. 14 Issue 1, p34
Academic Journal
Hypertension in 52 patients was treated for 4 to 56 days with divided doses of 6 or 12 mg of trichlormethiazide and 0.3 mg of reserpine daily in combination tablets. Blood pressure in all patients was lowered; the mean average was 33/16 mm Hg. Most patients also lost weight; the mean average was 4.2 pounds. Laboratory studies indicated that the drugs did not significantly change pretreatment values for serum electrolytes, serum carbon dioxide, nonprotein nitrogen, urinary sugar or albumin, or blood chemistry. There were no clinical side effects attributable to the drugs except a pruritic rash in an elderly male patient. The results of the clinical and laboratory studies did not differ between patients treated for long or short periods of time or between patients who received 6 or 12 mg of trichlormethiazide daily. It is concluded that the combination of trichlormethiazide and reserpine provides safe and effective management of hypertension.


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