TITLE

CLINICAL AND LABORATORY STUDY OF TRICHLORMETHIAZIDE AND RESERPINE IN 52 PATIENTS WITH HYPERTENSION

AUTHOR(S)
Baugh, James E.
PUB. DATE
January 1963
SOURCE
Angiology;Jan1963, Vol. 14 Issue 1, p34
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Hypertension in 52 patients was treated for 4 to 56 days with divided doses of 6 or 12 mg of trichlormethiazide and 0.3 mg of reserpine daily in combination tablets. Blood pressure in all patients was lowered; the mean average was 33/16 mm Hg. Most patients also lost weight; the mean average was 4.2 pounds. Laboratory studies indicated that the drugs did not significantly change pretreatment values for serum electrolytes, serum carbon dioxide, nonprotein nitrogen, urinary sugar or albumin, or blood chemistry. There were no clinical side effects attributable to the drugs except a pruritic rash in an elderly male patient. The results of the clinical and laboratory studies did not differ between patients treated for long or short periods of time or between patients who received 6 or 12 mg of trichlormethiazide daily. It is concluded that the combination of trichlormethiazide and reserpine provides safe and effective management of hypertension.
ACCESSION #
16395526

 

Related Articles

  • Papaverine.  // Reactions Weekly;9/23/2006, Issue 1120, p14 

    This article presents a case study involving an elderly male patient who developed refractory hypotension after receiving intracisternal papaverine following surgical clipping of his aneurysm. The hypotension of the patient was resistant to treatment with intravenous fluids and inotropes over...

  • Can Erectile Dysfunction Drug Use Lead to Ischaemic Optic Neuropathy? Pomeranz, H. D. // British Journal of Ophthalmology;Feb2006, Vol. 90 Issue 2, p127 

    The article focuses on the association of erectile dysfunction drug (EDD) use as a risk factor of non-arteritic anterior ischemic optic neuropathy (NAION). NAION is a frequent cause of untreatable, sudden, irreversible vision loss in individuals older than 40 years old. Most cases of NAION...

  • Enalapril.  // Reactions Weekly;4/8/2006, Issue 1096, p10 

    Provides information on the case of a woman who used enalapril to treat hypertension. Side effects of the drug; Results of the diagnosis of the patient; Treatment received by the patient for the complications.

  • Aliskiren well tolerated and effective in severe hypertension.  // Reactions Weekly;11/10/2007, Issue 1177, p3 

    The article deals with a multicentre study which investigated the impact of aliskiren in patients with severe hypertension. Some of the most frequently reported side effects of aliskiren include headache, nasopharyngitis, dizziness and fatigue. It compares the blood-pressure lowering efficiency...

  • CLINICAL EXPERIENCES WITH RESERPINE (SERPASIL) IN HYPERTENSION. Kert, Morley J.; Carleton, Henry G.; Nordyke, Robert A.; Roth, Samuel I.; Smith, Allen; Westergart, John P. // Angiology;Apr1955, Vol. 6 Issue 2, p138 

    Reserpine was administered to 63 ambulatory hypertensive patients. The dosage ranged from 0.5 to 8.0 mg for as long as 40 weeks. Approximately 40 per cent of the group experienced a significant decrease in diastolic blood pressure after receiving the drug. With the dosage employed, there was a...

  • Antipsychotic-Like vs Cataleptogenic Actions in Mice of Novel Antipsychotics Having D2 Antagonist and 5-HT1A Agonist Properties. Bardin, Laurent; Kleven, Mark S.; Barret-Grévoz, Catherine; Depoortère, Ronan; Newman-Tancredi, Adrian // Neuropsychopharmacology;Sep2006, Vol. 31 Issue 9, p1869 

    A new generation of proven or potential antipsychotics, including aripiprazole, bifeprunox, SSR181507 and SLV313, exhibit agonist actions at serotonin 5-HT1A receptors, but little comparative data are available on their pharmacological profiles. Here, we compared in mice the in vivo...

  • Informatics applied to pharmacovigilance: Future perspectives. Menniti, Michele; Menniti, Annamaria; Patanè, Marinella; Esposito, Stefania; Giofrè, Chiara; Aiello, Rossana; Russo, Emilio // Journal of Pharmacology & Pharmacotherapeutics;Dec2013 Supplement 1, Vol. 4 Issue 5, p43 

    Spontaneous adverse drugs reaction (ADRs) reporting represents a precious resource for control and information about the drug's safety and pharmacovigilance. The current reporting system is mainly based on handwritten forms and later manually loaded into a national electronic database by few...

  • Alemtuzumab.  // Reactions Weekly;9/22/2007, Issue 1170, p7 

    The article describes the case of a 68-year-old man who experienced acute transformation of cutaneous T cell lymphoma during treatment with alemtuzumab. He was given ganciclovir for 7 days, followed by valganciclovir. His fever was resolved and the cytomegalovirus (CMV) viraemia became negative...

  • Azathioprine.  // Reactions Weekly;9/22/2007, Issue 1170, p10 

    The article describes the case of a man receiving azathioprine for Crohn's disease who developed peliosis hepatis, portal hypertension and cholestatic hepatitis after three episodes of alcohol binging. Azathioprine was discontinued and he received corticosteroid pulse therapy. Results of his...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics