Calesnick, Benjamin
January 1963
Angiology;Jan1963, Vol. 14 Issue 1, p17
Academic Journal
Because of the lack of adequate methods, great confusion still exists regarding the precise mechanism of action of drugs used in the treatment of coronary artery disease. In most instances no definite statement can be made. It is a relatively simple matter to determine experimentally whether a drug increases or decreases coronary blood flow with the heart in situ. This does not necessarily indicate, however, that such a drug will have clinical utility. Finally, it is important to remember that the best pharmacology has to offer at present is a group of drugs which tend to modify existing coronary disease, thereby producing symptomatic remissions. Until an agent is discovered that will reverse underlying pathologic processes, currently available drugs can only be relied on to �slowdown� the progress of changes relative to this disease.


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