TITLE

The Hemodynamic Effects of Calcium Channel Blocking Agents: A Brief Review

AUTHOR(S)
Kieval, Joshua; Myerburg, Robert J.
PUB. DATE
August 1982
SOURCE
Angiology;Aug1982, Vol. 33 Issue 8, p516
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents the hemodynamic effects of calcium channel blocking agents. Calcium ions play important roles in a variety of biologic processes. In the cardiovascular system, calcium is involved in the generation of the cardiac action potential: it couples excitation to muscular contraction and it controls energy storage and utilization. Myocardial cell membrane depolarization is mediated by two inward currents: a kinetically fast current carried by sodium and a kinetically slower current carried primarily, but not exclusively, by calcium ions. In contrast with the effect on myocardial cells, increases in cyclic AMP in vascular smooth muscle cells result in relaxation and vasodilation.
ACCESSION #
16395465

 

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