Serum Theophylline Concentrations and Pulmonary Mechanical Functions Following Single and Steady-State Dosing with a Sustained-Release Theophylline Capsule

Falliers, Constantine J.
November 1978
Angiology;Nov1978, Vol. 29 Issue 11, p852
Academic Journal
The author in this article states that the management of chronic bronchial asthmatics around the clock sometimes is difficult and there is great difficulty in managing nocturnal asthmatics. The underlying causes for the occurrence of nocturnal asthma attacks, are not clearly understood, however, a decline of the drug level in the circulating blood may be claimed as one of the many causes for induction of nocturnal attacks. In this article, the feasibility of clinical usage of a newly introduced sustained release formulation of theophylline in maintaining bronchodilation and serum level at therapeutic ranges is discussed.


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