TITLE

Double-Blind Trial of Oral Papaverine in Chronic Cerebrovascular Ischemia

AUTHOR(S)
Shaw, Terry G.; Meyer, John Stirling
PUB. DATE
November 1978
SOURCE
Angiology;Nov1978, Vol. 29 Issue 11, p839
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A preliminary analysis of the effect of long-term therapy with oral papaverine has been made in 11 patients with chronic cerebral ischemia due to cerebral arteriosclerosis. The cases were classified as remote cerebral infarction (6 patients) or vertebrobasilar arterial insufficiency (5 patients). The patients received 225 mg or 450 mg daily, assigned in a double-blind manner. Most showed clinical improvement and improvement on the EEG. There was a statistically significant increase in regional cerebral blood flow in the vertebrobasilar arterial distribution, including the brain stem and cerebellar and posterior cerebral regions, particularly in the right hemisphere. Evidence appears to indicate that zones of severe remote cerebral infarction are refractory to pharmacologically induced vasodilation.
ACCESSION #
16395360

 

Related Articles

  • Suramin reduces infarct volume in a model of focal brain ischemia in rats. Kharlamov, Alexander; Jones, Stephen C.; Kim, Kyle D. // Experimental Brain Research;Dec2002, Vol. 147 Issue 3, p353 

    Extracellular adenosine 5'-triphosphate (ATP) provides excitatory transmission in the central nervous system. Stimulation by ATP of ionotropic ligand-gated ion channel purinoceptors (P2X) leads to increased intracellular calcium levels, and activation of P2X receptors may be involved in the...

  • Taxifolin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-oxidative effect and modulation of NF-kappa B activation. Yea-Hwey Wang; Wen-Yen Wang; Chia-Che Chang; Kuo-Tong Liou; Yen-Jen Sung; Jyh-Fei Liao; Chieh-Fu Chen; Shiou Chang; Yu-Chang Hou; Yueh-Ching Chou; Yuh-Chiang Shen // Journal of Biomedical Science;Jan2006, Vol. 13 Issue 1, p127 

    Infarction in adult rat brain was induced by middle cerebral arterial occlusion (MCAO) followed by reperfusion to examine whether taxifolin could reduce cerebral ischemic reperfusion (CI/R) injury. Taxifolin administration (0.1 and 1.0 μg/kg, i.v.) 60 min after MCAO ameliorated infarction (by...

  • SPECT Imaging and Cerebrovascular Disease. Valotassiou, Varvara; Wozniak, Greta; Sifakis, Nikolaos; Iliadis, Charalambos; Georgoulias, Panagiotis // Vascular Disease Prevention;Apr2007, Vol. 4 Issue 2, p165 

    Many studies promote both diagnostic and prognostic roles for single photon emission computed tomography (SPECT) functional brain imaging in patients with cerebrovascular disease (CVD). SPECT allows in vivo non-invasive imaging and quantification of regional cerebral blood flow (rCBF). Main...

  • Multiple Organ Manifestations in Thromboangiitis Obliterans (Buerger's Disease). Harten, Pontus; Müller-Huelsbeck, Stefan; Regensburger, Dieter; Loeffler, Helmut // Angiology;Apr1996, Vol. 47 Issue 4, p419 

    Thromboangiitis obliterans (TAO) occurs almost exclusively in young male smokers. Its involvement of the small and medium-sized arteries and veins leads to ischemic complaints and/or changes in the extremities. The possibility of organ involvement is a matter of controversy. The authors report a...

  • Experience with Buflomedil in Peripheral Arterial Occlusive Disease. Balas, P.; Pagratis, N. // Angiology;Oct1981, Vol. 32 Issue 10, p679 

    The article cites a study regarding experience with buflomedil in peripheral arterial occlusive disease. This study concerns the use of buflomedil in the treatment of patients with chronic peripheral arterial occlusive disease of the lower extremities and various degrees of ischemia. It was...

  • PERIPHERAL ARTERIOSCLEROSIS. Totten, H. P. // Angiology;Oct1954, Vol. 5 Issue 5, p355 

    Successful conservative surgery in peripheral arteriosclerosis is largely dependent upon the integrity of the arteries below the bifurcation of the popliteal. Because of the tendency for thrombosis to occur in the tibial arteries secondary to segmental obstruction of the aorta, iliac and femoral...

  • EXPERIMENTAL CEREBRAL ISCHEMIA. Wright, R. Lewis // Angiology;Jul1965, Vol. 16 Issue 7, p397 

    Experimental production of cerebral ischemia in both cats and rabbits has been attempted using as an initial procedure occlusion of the basilar artery. Both preparations suggest that the period of temporary ischemia compatible with life does not exceed 6 to 8 minutes.

  • Using PET to identify carotid occlusion patients at high risk of subsequent stroke: further insights. Baron, J-C. // Journal of Neurology, Neurosurgery & Psychiatry;Dec2004, Vol. 75 Issue 12, p1659 

    The article focuses on the identification of patients at high risk of subsequent stroke to implement appropriate prevention. Although atherothrombotic occlusion of the internal carotid artery can cause a devastating stroke. In many instances it is a benign event, causing only transient ischaemic...

  • Brain Ischemia Following Bilateral Carotid Occlusion During Development of Hypertension in Young Spontaneously Hypertensive Rats--Importance of Morphologic Changes of the Arteries of the Circle of Willis. Kusuda, Kenji; Ibayashi, Setsuro; Sadoshima, Seizo; Ishitsuka, Takao; Fujishima, Masatoshi // Angiology;May1996, Vol. 47 Issue 5, p455 

    The present study was designed to examine the effect of morphologic changes of the arteries of the circle of Willis on cerebral blood flow (CBF) and metabolism in young spontaneously hypertensive rats (SHR). CBF in the parietal cortex was measured by the hydrogen clearance method before and...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics