Noninvasive Assessment of Load Reduction in Chronic Congestive Heart Failure Patients

Gould, Lawrence; Reddy, C. V. R.; Patel, S.; Gomes, G. I.; Becker, William H.
August 1981
Angiology;Aug1981, Vol. 32 Issue 8, p552
Academic Journal
This article focuses on the noninvasive assessment of load reduction in chronic congestive heart failure patients. A reduction in impedance or afterload should produce beneficial hemodynamic effects in patients with left ventricular volume overload due to aortic insufficiency or mitral insufficiency. This has been verified using an IV infusion of nitroprusside, phentolamine, and hydralazine. The effects of vasodilators on left ventricular wall stress can now be evaluated noninvasively. This study was undertaken to evaluate left ventricular wall stress in patients with left ventricular volume overload and to determine the response of the patients to impedance reduction with oral phentolamine. Wall stress was determined using a noninvasive echocardiographic technique previously shown to correlate with values obtained by invasive methods.


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