Quick, Armand J.
October 1959
Angiology;Oct1959, Vol. 10 Issue 5, p386
Academic Journal
The fluidity of the blood is maintained and safeguarded by (1) the relative slowness of thrombin generation in blood, and (2) the prompt removal of thrombin from circulating blood. The slowness of thrombin production is due in part to the absence of preformed thromboplastin in the blood, the barriers that prevent the entrance of tissue thromboplastin, and the chemical stability of the primary clotting factors. The speed of the clotting reaction depends on thrombin, the agent, through which the autocatalytic reaction is mediated. In the absence of thrombin the clotting reaction cannot proceed. Thrombin is promptly and effectively removed from blood by virtue of its affinity for fibrin surface. When thrombin is generated in the blood or is injected intravenously, the fibrin fibrils that are produced adsorb it, thereby removing it promptly. Presumably both the fibrin filaments and the adsorbed thrombin are destroyed in the capillary bed. By virtue of this mechanism, no accumulation of thrombin is permitted and the potential chain reaction is effectively checked.


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