Buzzi, Alfredo
October 1959
Angiology;Oct1959, Vol. 10 Issue 5, p333
Academic Journal
Plethysmographic evidence of reduction of digital pulse volume in the injected limb, after the intraarterial administration of Tolazoline in doses of 30 to 80 mg in 5 patients with atherosclerosis obliterans and moderate arterial stenosis is reported. The observed reduction appeared 2 to 5 minutes after the injection and persisted for 20 to 30 minutes, with a return to the initial values or a late increase of digital pulse volume. Changes in skin temperature did not parallel plethysmographic observations. A significant increases of skin temperature of the proximal parts (thigh, knee), however, was observed. In another 5 patients with atherosclerotic occlusion and advanced arterial insufficiency, the initial plethysmographic values were too low to permit the detection of a further reduction. The diminution of digital pulse volume was not observed after isolated puncture of the femoral artery without the injection of vasodilators, find conversely, it was produced, although to a lesser degree, after the intravenous injection in 2 of 3 patients. It is postulated that these findings suggest the development of a predominant vasodilation of the proximal and suprastenotic vessels, with a transient reduction of digital blood flow. It is concluded that the objective evaluation of the results of intraarterial therapy is advisable in order to detect those patients that develop a reduction of the digital circulation.


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