TITLE

A Computer Program for Determining Vmax from the Uncalibrated Left Ventricular Pressure Signal and its First Derivative

AUTHOR(S)
Stefadouros, Miltiadis A.; Williams, Maryon J.
PUB. DATE
July 1981
SOURCE
Angiology;Jul1981, Vol. 32 Issue 7, p489
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A computer program was developed to simplify the conventional method for determining the maximal contractile element shortening velocity at zero load (Vmax) by analysis of pressure-velocity graphs during the isovolumic contraction period. From an uncalibrated left ventricular (LV) pressure signal and its first derivative (dP/dt), the graph relating developed LV pressure (Pd) to the corresponding instantaneous value of (dP/dt)/28 Pd was constructed by the computer. The segment of the graph that encompassed approximately the second half of the isovolumic contraction period, as determined by analysis of the dP/dt waveform, was then extrapolated to provide Vmax on the ordinate. This Vmax was compared with the conventional Vmax obtained from calibrated LV and aortic pressure signals. In 5 dogs both in the control state and during inotropic (epineprine, propranolol) and noninotropic interventions (phenylephrine or dextran infusion), a high degree of correlation was found relating Vmax and Vmax both derived by either linear (Vmax = 0.91 Vmax + 0.14; r = 0.933; P < 0.001) or exponential (V'max = 0.99 Vmax - 0.06; r = 0.959; P < 0.001) extrapolation of the pressure-velocity graph to zero load. By use of this program, Vmax can be easily and reliably estimated from the uncalibrated LV pressure signal and its first derivative.
ACCESSION #
16394862

 

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