TITLE

Selectivity of Calcium Antagonism and Serotonin Antagonism with Respect to Venous and Arterial Tissues

AUTHOR(S)
Van Nueten, J. M.; Vanhoutte, P. M.
PUB. DATE
July 1981
SOURCE
Angiology;Jul1981, Vol. 32 Issue 7, p476
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article focuses on the selectivity of calcium antagonism and serotonin antagonism with respect to venous and arterial tissues. The article deals with two major aspects where arterial and venous smooth muscle differ in their sensitivity to vasoactive agents, their sensitivity to inhibitors of calcium-influx on the one hand and their reactivity to serotonin and serotonin antagonists, on the other. Contractions of vascular smooth muscle induced by various vasoactive substances all are due to an increase in cytoplasmic calcium, which can be derived from cellular stores or enters the cells from the extracellular space. The effect of a calcium antagonist on such contractile responses can provide information on the origin of the activator ion. These differential effects of cinnarizine illustrate that, in a given preparation, different vasoactive agonists recruit calcium in a different way.
ACCESSION #
16394857

 

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