TITLE

Influence of Non-Selective and Selective Beta Adrenoceptor Blockade on Isoxsuprine-Dependent Hemodynamic and Rheologic Changes

AUTHOR(S)
di Perri, T.; Forconi, S.; Guerrini, M.; Pecchi, S.; Pieragalli, D.; Cappelli, R.; Acciavatti, A.
PUB. DATE
April 1981
SOURCE
Angiology;Apr1981, Vol. 32 Issue 4, p257
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The infusion of isoxsuprine was followed by an increase of heart rate and calf blood flow and by a decrease of arterial diastolic pressure and blood viscosity both in normal controls and patients with peripheral obstructive arterial disease. The pre-treatment with a non-selective beta adrenoceptor blocker (propranolol) canceled all the isoxsuprine-dependent changes, while the pre-treatment with a selective beta adrenoceptor blocker (metoprolol) abolished only tachycardia and did not influence the increase of calf blood flow and the decrease of blood viscosity. These findings indicate the different role of vascular beta receptors in the regulation of muscular blood flow and suggest the phal-macologic possibility to unmask the beta2-dependent vasodilation.
ACCESSION #
16394653

 

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