Platelet Adhesiveness: Methodology for Testing in Humans
- Ticlid/Plavix formulary evaluation. // Drug Utilization Review;Dec2001, Vol. 17 Issue 12, p1
Presents information on platelet aggregation inhibitors, Clopidogrel (Plavix) from Bristol-Myers-Squibb/Sanofi and Ticlopidine (Ticlid) from Roche. Mechanism of action and pharmacokinetics of the drugs; Dosage and indications for use of the drugs; Safety and clinical trials of the drugs.
- Measurement of platelet reactivity of patients with cardiovascular disease on-treatment with acetyl salicylic acid: a prospective study. Awidi, Abdalla; Saleh, Akram; Dweik, Manar; Kailani, Baraah; Abu-Fara, Mohammed; Nabulsi, Rinad; Bener, Abdulbari // Heart & Vessels;Sep2011, Vol. 26 Issue 5, p516
Acetyl salicylic acid (ASA) and clopidogrel are extensively used in the prevention of cardiovascular disease. However, the responsiveness to ASA treatment may vary among individuals. This study was conducted to investigate the profile and prevalence of ASA resistance in cardiac patients. From...
- Sibrafiban. Dooley, M.; Goa, K.L. // Drugs;Feb1999, Vol. 57 Issue 2, p225
â–´ Sibrafiban is the orally administered, nonpeptide, double-prodrug of Ro 44-3888 which is a selective glycoprotein IIb/IIIa receptor antagonist. It is currently undergoing clinical trials for secondary prevention of cardiac events in patients stabilised after acute coronary syndromes....
- Editorial [Hot Topic:The Search for Novel Anti-Thrombotic Drug Targets (Executive Editor: Dermot Cox)]. Cox, Dermot // Current Pharmaceutical Design;Sep2007, Vol. 13 Issue 26, p2638
Atherosclerosis is the leading cause of death in the Western world and anti-thrombotic therapy plays a key role in the management of this disease. However, despite the importance of platelets in the disease process there has been little progress in developing novel anti-thrombotic agents....
- The Basis of Platelets. // Drugs;2010 Supplement 1, Vol. 70, p9
No abstract available.
- Identification of Potential Predisposition to Clinical Atherosclerosis: A Clinical Concept Based on Integration of Significant Blood Parameters with Platelet Aggregation Scores. Kaplan, Alexander; Kaplan, Svetlana; Marcoe, Karen F.; Sauvage, Lesler R.; Hammond, William P. // Clinical & Applied Thrombosis/Hemostasis;Jul1997, Vol. 3 Issue 3, p174
We sought to develop a predictive method, based on the integration of blood parameters found to be significantly associated with thrombosis and progression of atherosclerosis, that would be more accurate than primary reliance on elevation of separate risk factors. The study involved 1,034 male...
- Risk of bleeding and restenosis among chronic kidney disease patients undergoing percutaneous coronary intervention. Attallah, N.; Yassine, L.; Fisher, K.; Yee, J. // Clinical Nephrology;2005, Vol. 64 Issue 6, p412
Background: Bleeding risk is increased in renal failure due to impaired platelet adhesiveness. Patients who undergo percutaneous coronary intervention (PCI) are given multiple antiplatelet agents that increase that risk. We retrospectively tested the hypothesis that chronic kidney disease (CKD)...
- Effects of Atenolol and Propranolol on Platelet Aggregation in Moderate Essential Hypertension: Randomized Crossover Trial. Punda, Ante; Polić, Stojan; Rumboldt, Zvonko; Bagatin, Jugoslav; Marković, Vinko; Lukin, Ajvor // Croatian Medical Journal;2005, Vol. 46 Issue 2, p219
Compares the effects of a selective beta-blocker atenolol and a nonselective beta-blocker propanolol on platelet aggregation. Role of platelet aggregation and arterial hypertension in the development of atherosclerosis; Methodology of the study; Discussion on the results of the study.
- Biological efficacy of low versus medium dose aspirin after coronary surgery: results from a randomized trial [NCT00262275]. Lim, Eric; Cornelissen, Jacqueline; Routledge, Tom; Ali, Ayyaz; Kirtland, Stephen; Sharples, Linda; Sheridan, Kate; Bellm, Sarah; Munday, Helen; Large, Stephen // BMC Medicine;2006, Vol. 4, p12
Background: The beneficial effect of aspirin after coronary surgery is established; however, a recent study reported the inability of low doses (100 mg) to inhibit postoperative platelet function. We conducted a double-blind randomised trial to establish the efficacy of low dose aspirin and to...