Effects of Intravenous Phentolamine on Hemodynamics and Resting Pulmonary Gas Exchange in Man

Gould, Lawrence; Reddy, C. V. R.; Becker, William H.; Maeklin, Elissa E.
February 1980
Angiology;Feb1980, Vol. 31 Issue 2, p120
Academic Journal
The influence of intravenous phentolamine on hemodynamics, ventilation, and blood gases were studied in 22 patients with cardiac disease. Phentolamine produced a significant increase in the heart rate and cardiac index and a significant decrease in the mean arterial pressure, mean pulmonary artery pressure, left ventricular end diastolic pressure, peripheral vascular resistance, and pulmonary vascular resistance. There was no significant change in the arterial pH, PO2, PCO2, alveolar-arterial PO2, and the dead space-tidal volume ratio. The favorable hemodynamic responses are attributable to the fact that the vasodilator effect of phentolamine is predominately on the arteriolar resistance bed and much less on the venous capacitance bed. In addition, phentolamine has a positive inotropic action which is indirect and dependent on the release of norepinephrine.


Related Articles

  • Alpha-adrenergic receptor blockade by phentolamine increases the efficacy of vasodilators in penile corpus cavernosum. Kim, N N; Goldstein, I; Moreland, R B; Traish, A M // International Journal of Impotence Research;2000 Supplement 1, Vol. 12 Issue 1, pS26 

    Penile trabecular smooth muscle tone, a major determinant of erectile function, is highly regulated by numerous inter- and intracellular pathways. The interaction between pathways mediating contraction and relaxation has not been studied in detail. To this end, we investigated the functional...

  • Left Ventricular Wall Motion Improvement After Phentolamine: A Case Report. Gould, Lawrence; Patel, S.; Gomes, G.; Reddy, C.V.R. // Angiology;Jan1982, Vol. 33 Issue 1, p33 

    This article presents a case study of a 50-year-old male with chest pain of 5-minute duration, in which researchers will document that improvement in left ventricular wall motion can occur following the IV administration of phentolamine. Left ventricular wall motion abnormalities are commonly...

  • Phentolamine Therapy for Cocaine-Associated Acute Coronary Syndrome (CAACS). Gar Ming Chan; Sharma, Rahul; Price, Dennis; Hoffman, Robert S.; Nelson, Lewis S. // Journal of Medical Toxicology;Sep2006, Vol. 2 Issue 3, p108 

    Introduction: The emergency department (ED) evaluation of cocaine-associated acute coronary syndrome (CAACS) is often a diagnostic and therapeutic challenge. Case report: We are reporting on the treatment of a patient with cocaine-associated acute coronary syndrome (CAACS) who did not benefit...

  • Noninvasive Assessment of Left Ventricular Wall Stress in Chronic Congestive Heart Failure Patients. Gould, Lawrence; Gopalaswamy, C.; Chandy, F.; Abdou, O. // Angiology;Feb1983, Vol. 34 Issue 2, p111 

    In 1969, our group first reported that the intravenous administration of phentolamine can improve cardiac performance in patients with heart failure. Positive inotropism and a reduction in afterload were shown to be the mechanisms that led to cardiac improvement. Since that time the literature...

  • The β-Adrenergic Receptor of Newborn Mouse Skin. Solanki, Virendra; Murray, Andrew W. // Journal of Investigative Dermatology;Nov78, Vol. 71 Issue 5, p344 

    Binding of the potent β-adrenergic antagonist [125I]iodohydroxybenzylpindolol ([125I]IHYP) to particulate preparations from newborn mouse skin was characterized. A number of criteria were used to establish that binding occurred to specific, high affinity β-adrenergic receptors in the skin...

  • THE INHIBITION OF THE EPINEPHRINE--THYROXIN INDUCED ARTERIOSCLEROSIS BY PHENTOLAMINE. Mikulicich, George F.; Oester, Tom Y. // Angiology;Jul/Aug1970, Vol. 21 Issue 7, p421 

    The article presents information on the inhibition of the epinephrine-thyroxin induced arteriosclerosis by phentolamine. Epinephrine induced aortie selerosis has first been described by a scientist in 1903. Since then a volumnious literature been summarized. Similar results have been obtained in...

  • Adrenergic Influences on the Gallbladder Emptying. Lechin, Fuad; Van Der Dijs, Bertha; Bentolila, Ana; Peña, Francisco // American Journal of Gastroenterology;Jun1978, Vol. 69 Issue 6, p662 

    Dihydroergotamine (DHE) (or phentolamine), an alpha-adrenergic blocking agent, induced important changes on the CCK-stimulated gallbladder emptying of 70 volunteer subjects. Two cholecystograms were performed with 10-day intervals in each subject. The first cholecystogram showed gallbladder...

  • THE EFFECTS OF ALPHA--ADRENERGIC RECEPTOR BLOCKADE AND SYMPATHETIC DENERVATION ON THE PRESSOR ACTION OF ANGIOTENSIN IN MAN. Scroop, G.C.; Whelan, R.F. // Australian Journal of Experimental Biology & Medical Science;Oct1968, Vol. 46 Issue 5, p563 

    Investigates the effects of alpha-adrenergic receptor blockade and sympathetic denervation on the pressor action of angiotensin in man. Determination of the modification in the blood pressure response; Indication of the failure of the phentolamine to modify the pressor response to angiotensin.

  • Nonaqueous capillary electrophoresis conditions for the simultaneous separation of eight alpha-adrenergic blocking agents. Qinhua Chen; Peng Li; Handong Yang; Bing Li; Jun Zhu; Lin Peng // Analytical & Bioanalytical Chemistry;Sep2010, Vol. 398 Issue 2, p937 

    The analysis is described for the first time for separating eight alpha-adrenergic blocking agents (oxymetazoline, 5-methylurapidil, prazosin, phentolamine, RS-17053, methoxamine, yohimbine, and BMY7378) by capillary electrophoresis (CE) with UV detection. Optimum separation of the analytes was...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics