Systemic Arterial Compliance and Diastolic Runoff in Essential Hypertension

Levenson, Jaime A.; Safar, Michel E.; Simon, Alain C.; Kheder, Adel I.; Daou, Joseph N.; Levy, Bernard I.
June 1981
Angiology;Jun1981, Vol. 32 Issue 6, p402
Academic Journal
Systemic arterial compliance was estimated in 31 men, including 15 patients with sustained essential hypertension and 16 normal subjects of the same age. Values were derived from analysis of the monoexponential blood pressure-time curve during diastole, according to a simple viscoelastic model. In normal subjects, baseline arterial compliance was 2.56 ± 0.18 ml/mm Hg. A significant decrease (1.88 ± 0.13 ml/mm Hg; P < 0.001) was observed in hypertensives. Administration of vasoactive substances (angiotensin and sodium nitroprusside) showed that, for the same blood pressure levels, normal subjects and hypertensives had similar values for compliance. However, the correlation between the basal values of diastolic pressure and compliance was significant in normal subjects (r = -0.76) but not in hypertensives (r = -0.33); these results suggested differences between acute and long-term conditions in patients and controls. Calculated diastolic runoff was similar in both groups, approximating 58 and 55% of the stroke volume respectively. This study provides evidence that, in sustained essential hypertension, (1) the reduced arterial compliance cannot be related exclusively to the level of blood pressure, but also requires some abnormality of the volume of large arteries, and (2) the reservoir role of the large arteries is maintained.


Related Articles

  • Potassium and norepinephrine- or angiotensin-mediated pressor control in pre-hypertension. Bianchetti, Mario G.; Weidmann, Peter; Beretta-Piccoli, Carlo; Ferrier, Claudia // Kidney International;Apr1987, Vol. 31 Issue 4, p956 

    Blood pressure (BP), plasma electrolytes, renin, aldosterone, angiotensin 11 (AII) or catecholamines, the chronotropic effects of intravenous isoproterenol. norepinephrine (NE)or AII, the pressor responses to NE or AII, and the relationship between plasma AII and aldosterone concentrations were...

  • Efficacy and Safety of Olmesartan in the Treatment of Mild-to-Moderate Essential Hypertension in Chinese Patients. Chiau-Suong Liau; Chii-Ming Lee; Sheng-Hsiung Sheu; Kwo-Chang Ueng; Kuo-Liong Chien; Ta-Chen Su; Wen-Ter Lai; Ming-Cheng Lin; Cheng-Sheng Lin; Chung-Sheng Lin // Clinical Drug Investigation;2005, Vol. 25 Issue 7, p473 

    Background and objective: Hypertension is very prevalent in the Chinese population in Taiwan. Chinese people frequently experience bothersome cough when receiving angiotensin-converting enzyme (ACE) inhibitors, and angiotensin II (AT1) receptor antagonists are thus relatively more frequently...

  • Angiotensin-II receptor blockers: benefits beyond blood pressure reduction? Volpe, M; Ruilope, LM; McInnes, GT; Waeber, B; Weber, MA // Journal of Human Hypertension;May2005, Vol. 19 Issue 5, p331 

    Effective treatment of hypertension is essential to reduce the risk of renal and cardiovascular (CV) morbidity. The risks associated with hypertension are modulated by the presence of other factors. This has prompted the quest for agents that have benefits beyond blood pressure (BP) lowering....

  • High-dose monotherapy vs low-dose combination therapy of calcium channel blockers and angiotensin receptor blockers in mild to moderate hypertension. Andreadis, E. A.; Tsourous, G. I.; Marakomichelakis, G. E.; Katsanou, P. M.; Fotia, M. E.; Vassilopoulos, C. V.; Diamantopoulos, E. J. // Journal of Human Hypertension;Jun2005, Vol. 19 Issue 6, p491 

    The objectives of the study were to compare long-acting dihydropyridine calcium channel blockers (CCBs) with angiotensin II receptor blockers (ARBs) according to the ambulatory blood pressure monitoring (ABPM) profile in stage 1 and 2 newly diagnosed hypertensives and also to evaluate the...

  • Aliskiren Monotherapy Results in the Greatest and the Least Blood Pressure Lowering in Patients With High- and Low-Baseline PRA Levels, Respectively. Stanton, Alice V.; Dicker, Patrick; O'Brien, Eoin T. // American Journal of Hypertension;Sep2009, Vol. 22 Issue 9, p954 

    Hypertensive patients with low-baseline plasma renin activity (PRA) are known to respond best to natriuretic drugs, and those with high PRA respond best to renin–angiotensin system (RAS) blockade. However, there has been recent speculation that blood pressure (BP)–lowering...

  • Recognizing and treating two types of long-term vasoconstriction in hypertension. Laragh, John H.; Resnick, Lawrence M. // Kidney International Supplement;Sep1988, Issue 25, p162 

    Long considered a single clinical entity, essential hypertension is now recognized as a heterogeneous spectrum of pathophysiologic disturbances, based on extensive clinical, pharmacologic and biochemical evidence. Two distinctly different mechanisms for long-term vasoconstriction can be...


    Studies the role of the renin-angiotensin system in the initiation of renovascular hypertension in unilaterally nephrectomized dogs with renal artery constriction. Administration of the nonapeptide Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro to the nephrectomized dogs to determine whether the rise in...

  • Effects of allisartan, a new AT1 receptor blocker, on blood pressure and end-organ damage in hypertensive animals. Ming-yue WU; Xiu-juan MA; Chu YANG; Xia TAO; Ai-jun LIU; Ding-feng SU; Jian-guo LIU // Acta Pharmacologica Sinica;Mar2009, Vol. 30 Issue 3, p307 

    AbstractAim:To investigate the effects of allisartan, a new angiotensin II type 1 (AT1) receptor antagonist, on blood pressure (BP) and end-organ damage (EOD) in hypertensive rats and dogs.Methods:First, a single dose of allisartan was given intragastrically to evaluate the BP reduction in...

  • Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: Role of NADPH oxidase. Sarr, Mamadou; Chataigneau, Marta; Martins, Sandrine; Schott, Christa; El Bedoui, Jasser; Oak, Min-Ho; Muller, Bernard; Chataigneau, Thierry; Schini-Kerth, Val�rie B. // Cardiovascular Research;Sep2006, Vol. 71 Issue 4, p794 

    Abstract: Objective: Chronic administration of moderate amounts of red wine has been associated with a protective effect on the cardiovascular system. This study examined whether red wine polyphenols prevent the angiotensin II (Ang II)-induced hypertension and endothelial dysfunction in rats,...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics