Inhibitory Effect of Urografin 76 on Platelet Function and Thrombus Formation in Vascular Catheters

Motomiya, Takeshi; Yamazaki, Hiroh
April 1980
Angiology;Apr1980, Vol. 31 Issue 4, p283
Academic Journal
The effect of Urografin 76 on platelet aggregation and thrombus formation in vascular catheter was studied. In vitro experiments revealed that ADP-, epinephrine-, and collagen-induced platelet aggregation was significantly inhibited by Urografin 76 in concentrations greater than 0.3, 1, and 5% respectively. Rabbits that received 10 ml of Urografin 76 demonstrated a transient decrease in platelet aggregation for at least 3 minutes. Urografin 76 was apparently more effective than saline in preventing blood clot formation.


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