Angiokines, Angiogenesis and Angiolymphoproliferative Syndromes (ALPS)

DeCarvalho, Sergio
April 1983
Angiology;Apr1983, Vol. 34 Issue 4, p231
Academic Journal
In earlier experiments we had noted that transformed and leukemic leukocytes produced an RNA-rich angiogenic lymphokine. The formation of capillaries is a stepwise process in which reticulum cells first become detached and attracted to a site (mobilization and migration along a reticulin network). This is followed by local proliferation and finally by elongation and alignment against a basal membrane in tubular geometry. Coincidental with the last step is a biochemical and immunochemical differentiation of the endothelial cells manifested by the appearance of alkaline phosphatase, angiotensin-converting enzyme, factor VIII and the generation of receptors for thrombin as well as the capacities to produce prostacyclin and fibronectin on demand. It is postulated that there may be not one but several angiogenic lymphokines (angiokines) for each step of capillary development. Angiokine 1 (AK1) for the mobilization-chemotactic-migration, AK2 for the local proliferative, and AK3 for differentiating-morphogenic events. The above postulate aids in the classification and understanding of a number of angiolymphoproliferative syndromes since these reflect different disorders of the stepwise vessel formation. The association and the simultaneous proliferation of vascular and lymphoid elements is a feature that a number of lymphoproliferative disorders, of otherwise differing nature, have in common. To this effect they have been grouped in this study as angiolymphoproliferative syndromes (ALPS). These are a group of prelymphomatous or prelymphomogenic clinicopathologic entities in which proliferation of a lymphoid element (cell) is coupled with the accelerated development of blood capillaries and postcapillary venules.


Related Articles

  • Lymphoproliferative Disorders and Chemokines. Pistoia, V.; Corcione, A.; Dallegri, F.; Ottonello, L. // Current Drug Targets;Jan2006, Vol. 7 Issue 1, p81 

    Chemokines are low molecular weight cytokines specialized in leukocyte recruitment. Recent studies have shown that tumor cells of hematopoietic and non hematopoietic origin express different chemokine receptors that may be involved in neoplastic cell growth, metastasis and angiogenesis. Human...

  • Minimal residual disease is an important predictive factor of outcome in children with relapsed ‘high-risk’ acute lymphoblastic leukemia. Paganin, M.; Zecca, M.; Fabbri, G.; Polato, K.; Biondi, A.; Rizzari, C.; Locatelli, F.; Basso, G. // Leukemia (08876924);Dec2008, Vol. 22 Issue 12, p2193 

    The aim of the study was to analyze the impact of minimal residual disease (MRD) after reinduction therapy on the outcome of children with relapsed ‘high-risk’ acute lymphoblastic leukemia (ALL). Sixty patients with isolated or combined marrow relapse were studied. All patients...

  • Epigenetic changes in the repression and induction of asparagine synthetase in human leukemic cell lines. Ding, Y; Li, Z; Broome, J. D // Leukemia (08876924);Mar2005, Vol. 19 Issue 3, p420 

    In common with certain other lymphoid neoplasms, cells of the human lymphocytic leukemia lines 1873 and 1929 are asparagine (ASN) auxotrophs. Asparagine synthetase (ASY), which is a housekeeping gene, is repressed and the promoting region of the gene is highly methylated. We now demonstrate in...

  • Long-Term Variations in Human T Lymphotropic Virus (HTLV)-I and HTLV-II Proviral Loads and Association with Clinical Data. Kwaan, Nicholas; Tzong-Hae Lee; Chafets, Daniel M.; Nass, Catharie; Newman, Bruce; Smith, James; Garratty, George; Murphy, Edward L. // Journal of Infectious Diseases;12/1/2006, Vol. 194 Issue 11, p1557 

    Background. The human T lymphotropic virus (HTLV)—I or —II proviral load (VL) may be linked to viral pathogenesis, but prospective data on VL and disease outcomes are lacking. Methods. Using data from a prospective cohort study of HTLV disease outcomes, we examined baseline VLs...

  • Bacillary Angiomatosis in a Patient with Chronic Lymphocytic Leukemia. Petersen, K.; Earhart, K.; Wallace, M. // Infection;Oct2008, Vol. 36 Issue 5, p480 

    Bacillary angiomatosis is a cutaneous or visceral infection with Bartonella henselae or Bartonella quintana. Cases usually occur in HIV infected individuals. We present a 60-year-old man with chronic lymphocytic leukemia and neutropenic fever caused by bacillary angiomatosis. The nine BA cases...

  • Clinical and Molecular Analysis of 49 Patients With X-linked Agammaglobulinemia From A Single Center in Argentina. Natalia Basile; Silvia Danielian; Matias Oleastro; Sergio Rosenzweig; Emma Prieto; Jorge Rossi; Adriana Roy; Marta Zelazko // Journal of Clinical Immunology;Jan2009, Vol. 29 Issue 1, p123 

    Abstract Introduction  Argentina has a large number of patients with definite diagnosis of X-linked agammaglobulinemia reported in the Latin-American registry. Forty-nine of them were seen in our referral pediatric hospital, between 1987 and 2005. Results and Discussion  A...

  • Linfoma anaplásico de células grandes tipo B cs enfermedad de Rosai-Dorfman. Reporte de un caso y revisión bibliográfica. Jiménez, Abraham Emilio Reyes; Vallejo, Rogelio David Castro; Marcelino, Morales Rivera; Gómez, Ixchel Landgrave; Vázquez, Iván Reyes; D'Franchis, Luis Javier Castro; López, Fernando Rogelio Espinosa // Medicina Interna de Mexico;may/jun2008, Vol. 24 Issue 3, p230 

    We report the case of a 68-year-old female with asthenia, fever and progressive malaise along with multiple mobile, painless, cervical bilateral linfadenopathy, which progressively increased in size. Diagnosed with Rosai-Dorfman disease five months prior. Diagnosis was based on fine needle...

  • Clinical Aspects and Genetic Analysis of Taiwanese Patients with Wiskott—Aldrich Syndrome Protein Mutation: The First Identification of X-Linked Thrombocytopenia in the Chinese with Novel Mutations. Lee, Wen-I; Huang, Jing-Long; Jaing, Tang-Her; Wu, Kang-Hsi; Chien, Yin-Hsiu; Chang, Kuei-Wen // Journal of Clinical Immunology;Jul2010, Vol. 30 Issue 4, p593 

    Wiskott–Aldrich syndrome (WAS) is an X-linked immunodeficiency characterized by microthrombocytopenia, eczema, and recurrent infections. However, the more than 500 patient mutations described are mainly based on Caucasian and Japanese populations. This study investigated Taiwanese...

  • Nasopharyngeal sarcoidosis: a rare involvement. Akin, Safak; Akin, Serkan; Karadag, Omer; Kalyoncu, Umut; Balcı, Serdar; Ozgen, Burce // Rheumatology International;May2012, Vol. 32 Issue 5, p1407 

    Sarcoidosis is a chronic, multisystemic, non-caseating granulomatous disease of unknown etiology. Nasopharyngeal involvement is very rare in sarcoidosis. The objective of this report was to evaluate a rare involvement of sarcoidosis. This report includes a case of nasopharyngeal sarcoidosis. A...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics