The Beneficial Effect of the Beta Blocker Timolol In Stable Angina Pectoris

Di Segni, Elio; Fidelman, Eva; David, Daniel; Klein, Herman O.; Kaplinsky, Elieser
April 1980
Angiology;Apr1980, Vol. 31 Issue 4, p238
Academic Journal
Timolol is a new beta blocker with cardioselective properties. A single blind controlled study was performed to assess the efficacy of timolol maleate in doses of 10 to 30 mg per day in 20 patients affected by stable angina pectoris. The patients received a placebo for a baseline period of 2 weeks, followed by 12 weeks of timolol. The number of anginal attacks dropped from 14.9 attacks per week in the baseline period to a minimum of 4.6 attacks per week in the sixth week of treatment (F C 0.01). The number of tablets of nitroglycerin taken per week was reduced from 6.5 during the baseline period to 2.3 in the sixth week of treatment. Resting heart rate decreased from a baseline mean value of 72 beats per minute to 51.7 and 53.7 per minute at weeks 6 and 12 respectively (P < 0.01). Blood pressure both at rest and during exercise was significantly reduced. The mean work index measured during bicycle ergometry was 127 units before treatment; it increased by 29.4 units and 36.1 units during week 6 and week 12 respectively (P < 0.05). There was a marked symptomatic improvement in 50% of the patients. Mild fatigue was a common side effect but it disappeared following reduction of dose. We concluded that timolol maleate significantly reduces the number of anginal attacks and increases the work capacity of patients affected by stable angina pectoris.


Related Articles

  • Betim.  // Royal Society of Medicine: Medicines;2002, p113 

    The article presents information on Betim, a proprietary, prescription-only preparation drug of the beta-blocker timolol maleate. This drug can used as an antihypertensive for high blood pressure, as an anti-angina treatment to relieve symptoms and improve exercise tolerance and to treat...

  • An Ongoing Debate: Should Beta Blockers Be Used for Primary Hypertension? Howard, Patricia A. // Hospital Pharmacy;Jan2007, Vol. 42 Issue 1, p22 

    The article focuses on the findings of several studies regarding the use of beta blockers in the treatment of primary hypertension (HTN). Research conducted by the British National Institute of Health and Clinical Evidence (NICE) found a higher risk of myocardial infarction (MI) with beta...

  • Beta-blocker efficacy dependent on genes.  // GP: General Practitioner;10/7/2005, p4 

    The article reports that researchers in the U.S. have found that how long a patient taking beta-blockers for an acute coronary syndrome will survive is largely determined by their genes. They looked at variations in the beta-adrenergic receptor genes in 597 patients who were treated with...

  • Clinical Relevance of Intrinsic Sympathomimetic Activity of Beta Blockers Used in Angina. Kostis, J. B.; DeFelice, E. A.; Frishman, W.; Hosier, M.; Krieger, S. K.; Aglitz, N.; Kuo, P. T. // Angiology;Nov1981, Vol. 32 Issue 11, p780 

    β-blockers are effective in the symptomatic relief of angina pectoris by decreasing myocardial oxygen demand during effort and emotional stress. Agents with ISA such as pindolol produce effective β-blockade during effort or emotional stress while conferring significant protection from...

  • Reports of diarrhoea with carvedilol.  // WHO Drug Information;2004, Vol. 18 Issue 3, p217 

    The article reports on cases of diarrhoea with the use of carvedilol. Carvedilol is a non-cardioselective beta-blocker with alpha blocking activity. It is indicated for the management of essential hypertension, angina pectoris and as adjunctive therapy in chronic heart failure. Diarrhoea is a...

  • Apical Hypokinesis in a Patient with Hypertrophic Cardiomyopathy and Myocardial Bridging: Reversal with Beta-Blockade. Rentoukas, Elias L.; Deftereos, Spiros G.; Alpert, Martin A.; Nikas, Dimitris J.; Lazaros, George A.; Petropoulou, Evdokia N.; Zacharoulis, Apostolos A. // Angiology;May1999, Vol. 50 Issue 5, p409 

    A 42-year-old man presented with effort angina pectoris of 20 minutes' duration. Hypertrophic obstructive cardiomyopathy, severe myocardial bridging involving the midleft anterior descending coronary artery, and apical hypokinesis were identified. Regional wall motion normalized following the...

  • Study: Inexpensive Four-Drug Combo Saves Heart Patients' Lives; 90 Percent Cut in Death Risk From Aspirin, Beta Blocker, ACE Inhibitor, Statin.  // Ascribe Newswire: Medicine;2/19/2004, p8 

    This article reports that heart attack and unstable angina patients who were prescribed all four types of proven medications had a 90 percent lower risk of dying in the six months after they left the hospital than those who received none of the drugs. The four classes of medications are:...

  • Angilol.  // Royal Society of Medicine: Medicines;2002, p61 

    The article provides information on Angilol, a proprietary, prescription-only preparation of the beta-blocker propranolol hydrochloride. It can be used as an antihypertensive for raised blood pressure, as an anti-angina treatment to relieve symptoms and to improve exercise tolerance and as an...

  • Timolol: a non-sedative anxiolytic premedicant for day cases. Mackenzie, John W.; Bird, Jane // BMJ: British Medical Journal (International Edition);2/11/89, Vol. 298 Issue 6670, p363 

    Examines the effects of oral timolol. Effectiveness of timolol in treating anxious patients; Advocation of short acting sedatives; Use of Beta Blockers in reducing situational anxiety.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics