TITLE

Detection of Early Myocardial Infarction by Radioimmunoassay of Myoglobin

AUTHOR(S)
McMurtry, John P.; Wexler, Bernard C.
PUB. DATE
December 1979
SOURCE
Angiology;Dec1979, Vol. 30 Issue 12, p806
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A newly devised radioimmunoassay for the measurement of myocardial myoglobin has been modified by us to measure circulating myoglobin levels in rats subjected to isoproterenol-induced myocardial infarction of various degrees of severity. The method has been found to be very effective. Myoglobinemia proved to be a sensitive index of early myocardial damage in rats, perhaps superseding the enzyme CPK in detecting early myocardial damage. Both myoglobin and CPK were equally effective in providing an index of the extent of histopathologic myocardial infarction. The changes in myoglobin and CPK did not correlate well with the changes in plasma SGOT, SGPT, and LDH, which are more diagnostic of the later stages of acute myocardial infarction. Myoglobinemia offers excellent promise as a diagnostic aid in detecting early myocardial infarction in rats, and perhaps ultimately in humans, since there are only small differences between the immunologic specificity of human versus rat myoglobin.
ACCESSION #
16390697

 

Related Articles

  • Diagnosis of Acute Coronary Syndrome. Achar, Suraj A.; Kundu, Suriti; Norcross, William A. // American Family Physician;7/1/2005, Vol. 72 Issue 1, p119 

    The term "acute coronary syndrome" encompasses a range of thrombotic coronary artery diseases, including unstable angina and both ST-segment elevation and non-ST-segment elevation myocardial infarction. Diagnosis requires an electrocardiogram and a careful review for signs and symptoms of...

  • Cardiac Biomarkers. Schreiber, Donald H.; Mattu, Amal // Practical Summaries in Acute Care;Aug2007, Vol. 2 Issue 8, p61 

    This article focuses on the clinical policy of the American College of Emergency Physicians (ACEP) on the diagnosis and management of acute non-ST segment elevation acute myocardial infarction (nSTEMI). ACEP has three level B recommendations for ruling out nSTEMI, which are a single negative...

  • Indicators of non-Q-wave acute myocardial infarction.  // American Family Physician;9/15/1995, Vol. 52 Issue 4, p1188 

    Reports on a study published by Cannon and colleagues in the May 15, 1995 issue of the `American Journal of Cardiology' comparing clinical features and developing a prediction rule to assist in distinguishing between non-Q-wave myocardial infarction and unstable angina.

  • Myocardial infarction: redefined or reinvented? Dargie, H. // Heart;Jul2002, Vol. 88 Issue 1, p1 

    Editorial. Explores the role of troponins in the diagnosis of acute myocardial infarction. Risk stratification of the disease; Redefinition of myocardial infarction.

  • Apical Balloon Syndrome (TAKO TSUBO STRESS CARDIOMYOPATHY) or Aborted Myocardial Infarction. Hanoman, H. H. // West Indian Medical Journal;Mar2010, Vol. 59 Issue 2, p232 

    The article discusses the diagnosis of a 44-year old man with an aborted myocardial infarction.

  • Changing the diagnostic criteria for myocardial infarction in patients with a suspected heart attack affects the measurement of 30 day mortality but not long term survival. Packham, C.; Gray, D.; Weston, C.; Large, A.; Silcocks, P.; Hampton, J. // Heart;Oct2002, Vol. 88 Issue 4, p337 

    Objectives: To explore the effects of alternative methods of defining myocardial infarction on the numbers and survival patterns of patients identified as having sustained a confirmed myocardial infarct. Design: An inclusive historical cohort of patients admitted with a suspected heart attack....

  • Coronary Angioplasty for Acute Myocardial Infarction. Topol, Eric J. // Annals of Internal Medicine;12/15/88, Vol. 109 Issue 12, p970 

    Presents a study which examined the role of coronary angioplasty for acute myocardial infection. Historical background on the occurrence of acute coronary thrombosis; Factors associated with the pathology of the disease; Approaches for coronary angioplasty.

  • Research Briefs - Estimates of MI risk.  // GP: General Practitioner;3/25/2011, p10 

    The article focuses on the research report according to which a sensitive troponin test can be used for detecting an coronary syndrome Myocardial infarction (MI) risk in the patients in the Great Britain.

  • Novel fusion of GLP-1 with a domain antibody to serum albumin prolongs protection against myocardial ischemia/reperfusion injury in the rat. Weike Bao; Lucy J Holt; Prince, Rob D.; Jones, Gavin X.; Aravindhan, Karpagam; Szapacs, Mathew; Barbour, April M.; Jolivette, Larry J.; Lepore, John J.; Willette, Robert N.; DeAngelis, Elena; Jucker, Beat M. // Cardiovascular Diabetology;2013, Vol. 12 Issue 1, p1 

    Background Glucagon-like peptide-1 (GLP-1) and its mimetics reduce infarct size in the setting of acute myocardial ischemia/reperfusion (I/R) injury. However, the short serum half-life of GLP-1 and its mimetics may limit their therapeutic use in acute myocardial ischemia. Domain antibodies to...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics