Jellinek, Harry
December 1970
Angiology;Dec1970, Vol. 21 Issue 11, p691
Academic Journal
Comparative studies on human material and their evaluation with regard to etiology and associated vascular changes have led to the conclusion that the fibrinoid necrosis of the vessel wall should be interpreted as an accompanying morphologic phenomenon rather than a characteristic lesion. The development of the vascular fibrinoid depends on the intensity and duration of vascular damage, but it is unrelated to the etiology. The various stages of the vascular lesion—initial muscle cell necrosis, plasma imbibition and fibrin formation—are not conclusive of the etiological factor. The morphological appearance of the lesion depends on the duration and intensity of the etiological factor, but is unrelated to its nature, as has been evidenced in human and experimental diseases.


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