TITLE

Antiarrhythmic Effects of Verapamil

AUTHOR(S)
Singh, Bramah N.; Nademanee, Koonlawee; Feld, Gregory
PUB. DATE
September 1983
SOURCE
Angiology;Sep1983, Vol. 34 Issue 9, p572
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article reports on antiarrhythmic effects of verapamil. Verapamil, a synthetic papaverine derivative, was first introduced in 1962 as a smooth muscle relaxant with potent vasodilator and antiarrhythmic properties. In recent years, verapamil has emerged as a prototype of an entirely new class of cardiovascular drugs. The recognition of such a class of agents has followed closely in the wake of the demonstration that the inward depolarizing current in the heart muscle,unlike that in nerve, can be separated into two discrete components with distinct electrophysiological properties. The first, a kinetically fast current ("fast response") is carried by sodium ions; it is sensitive to alterations in external sodium concentration and is selectively inhibited by tetrodotoxin.
ACCESSION #
16389232

 

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