Linduer, M. August; Hafkenschiel, Joseph H.
February 1958
Angiology;Feb1958, Vol. 9 Issue 1, p19
Academic Journal
Hexamethonium with reserpine was an effective depressor agent in 17 of 22 hypertensive patients having a good prognosis for survival, and who took the preparation for at least 1 year. The dose was individualized for each patient. In our series, it was not deemed necessary to hospitalize the patients, nor to teach them to take their own blood pressures. Our series compares favorably with the results reported by Dennis et al.8 and by Crawley et al.9 Patients with severe essential hypertension, having little evidence of renal, cardiac and retinal vascular damage are suitable candidates for a trial of oral hexamethonium with reserpine. The original dosage of reserpine (0.25 mg) in each tablet was considered to be larger than optimal for prolonged use, because of the possibility of producing intractable mental depression. This side effect was not, however, observed in our patients. During the past year the dosage per tablet has been changed to 0.125 mg. With this reduced dosage it is best not to use more than 1 tablet 4 times daily (total dose of reserpine 0.5 mg). Any further increase should be in hexamethonium alone.


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