TITLE

COMBINED EFFECTS OF ACUTE CEREBROVASCULAR ISCHEMIA AND MYOCARDIAL INFARCTION IN ARTERIOSCLEROTIC, MALE SPRAGUE-DAWLEY RATS

AUTHOR(S)
Wexler, Bernard C.
PUB. DATE
September 1977
SOURCE
Angiology;Sep1977, Vol. 28 Issue 9, p624
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Male breeder rats with early, generalized arterioscelerosis were subjected to unilateral carotid artery ligation .o induce a relative ischemia of the brain. They were then challenged with a myocardial infarct-inducing dose or isoproterenol causing severe convulsions, Horner's syndrome, and hours later, myocardial infarction and shock. The combined effects of ischemia of the heart and brain were associated with great exacerbation of the usual untoward changes that accompany acute ischemia of the brain and heart alone. The mortality rate was high, catabolic changes were intense, the heart and adrenal glands were greatly hypertrophied, serum enzymes (SGOT, SGPT, and LDH) and lipids (triglycerides, free fatty acids, and cholesterol) were acutely elevated, as were BUN and corticosterone levels. Histopathologically, their hearts showed unusually extensive and confluent endocardial and transmural necrosis accompanied by severe fatty infiltration of the liver with frequent foci of necrosis, advanced cerebral edema, and islet beta cell degranulation. It is suggested that the combined effects of ischemia of the heart and brain were synergistic, and
ACCESSION #
16389148

 

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