Kostis, John B.; Goodkind, M. Jay; Skvaza, H.; Gerber Jr., Norris H.; Kuo, Peter T.
September 1977
Angiology;Sep1977, Vol. 28 Issue 9, p583
Academic Journal
The atrial fibrillation threshold was measured in 10 anesthetized dogs by delivering a series of impulses directly to the right atrium after infusion of 4.5 ml of 5% glucose per kilogram of body weight, and after 1.5 ml of absolute alcohol per kilogram in 3 ml/kg of 5% glucose. There were no changes in the atrial fibrillation threshold after glucose. The mean AFT before alcohol was 6.8 volts. Immediately after alcohol infusion, the arterial blood alcohol concentration (BAC) was 300.7 mg/100 ml, and the AFT increased to 9.75 volts (P < 0.01); 20 minutes later the BAC was 181.2 mg/100 ml and the AFT 8.5 {P < 0.02). There was no rebound decrease in AFT up to 65 minutes. The findings suggest that in anesthetized normal dogs, alcohol may have a direct mild antiarrhythmic effect on the atria. Atrial fibrillation in alcoholics may be due to alcohol indirectly through electrolyte, autonomic, or histologic changes.


Related Articles

  • Antiarrhythmic Drug Therapy for Atrial Fibrillation: Focus on Atrial Selectivity and Safety. Li, D.; Sun, H.; Levesque, P. // Cardiovascular & Hematological Agents in Medicinal Chemistry;2009, Vol. 7 Issue 1, p64 

    Atrial fibrillation (AF) is a highly prevalent arrhythmia and responsible for significant morbidity, mortality and health care cost. The prevalence of AF is expected to increase markedly with the aging population. The use of conventional antiarrhythmic agents has been limited by potentially...

  • Propafenone.  // Reactions Weekly;11/10/2007, Issue 1177, p25 

    The article describes the case of a 74-year-old female patient who developed transient QRS widening after receiving propafenone for paroxysmal atrial fibrillation. The patient, who had started receiving propafenone 6 months previously, developed palpitations. She developed nausea, anorexia,...

  • Left atrial appendage functions in patients with severe rheumatic mitral regurgitation. Atila Bitigen; Mustafa Bulut; Ali Tanalp; Cevat Kirma; Irfan Barutçu; Selcuk Pala; Ayhan Erkol; Bilal Boztosun // International Journal of Cardiovascular Imaging;Dec2007, Vol. 23 Issue 6, p693 

    Abstract Aim  The left atrial appendage (LAA) function was evaluated in patients with severe rheumatic mitral regurgitation, having sinus rhythm or atrial fibrillation, by standard and tissue Doppler echocardiographic examinations. Methods and results  Sixty...

  • Bifocal versus unifocal right atrial pacing under plasma level controlled sotalol to prevent atrial fibrillation in patients with symptomatic sinus bradycardia and paroxysmal atrial fibrillation. Martin Stockburger; Lars Gerhardt; Stephan Helms; Michael Schlegl; Christian Butter // Herzschrittmachertherapie und Elektrophysiologie;Dec2007, Vol. 18 Issue 4, p250 

    Zusammenfassung Hintergrund   In vorangehenden Studien zur präventiven Therapie von Patienten mit paroxysmalem Vorhofflimmern (VHF) wurde bifokale rechtsatriale Stimulation (BS) bei gleichzeitiger antiarrhythmischer Therapie als effektive Strategie zur Verlängerung des...

  • Atrial fibrillation — the growing epidemic. Lip, Gregory Y. H.; Kakar, Puneet; Watson, Timothy // Heart;May2007, Vol. 93 Issue 5, p542 

    The author discusses the growing epidemic of atrial fibrillation. Atrial fibrillation is the most common sustained cardiac arrhythmia which has a projected incidence that is markedly increasing. It is estimated that approximately 3 million individuals in the U.S. will have atrial fibrillation by...

  • Atrial Fibrillation with a Focus on Oral Antiarrhythmic Therapy. von Vital, Jacqueline M.; DeEugenio, Deborah L.; Jackson, Anna Wodlinger; Kiernan, Thomas; Ruggiero II, Nicholas J. // Current Drug Therapy;Jan2011, Vol. 6 Issue 1, p65 

    Atrial fibrillation (AF) is considered the most common sustained arrhythmia resulting in significant morbidity, mortality, and cost. Management of AF includes rate control, prevention of thrombosis, and, in some patients, conversion and maintenance of normal sinus rhythm. Pharmacologic therapy...

  • Dronedarone: A Safety Comparison to Amiodarone. Clem, James R.; Farver, Debra K.; Fischer, Janet R.; Johnson, Thomas J. // Current Drug Safety;Jul2010, Vol. 5 Issue 3, p251 

    Dronedarone is an oral Class III antiarrhythmic agent which was recently approved by the US Food and Drug Administration for use in nonpermanent atrial fibrillation. Structurally similar to amiodarone, dronedarone is a benzofuran derivative but it lacks the iodine moiety attached to amiodarone....

  • Ablation vs Drug Therapy for Intermittent Atrial Fibrillation. DiMarco, John P. // Clinical Cardiology Alert;Feb2007, Vol. 26 Issue 2, p12 

    IN THIS PAPER PAPPONE AND HIS COLLEAGUES REPORT a randomized study comparing circumferential pulmonary vein ablation (CPVA) to antiarrhythmic drug therapy in patients with paroxysmal atrial fibrillation who had previously failed at least one trial with antiarrhythmic drugs. Patients were...

  • Update on Atrial Fibrillation: Restoration of Sinus Rhythm or Ventricular Rate Control? Yi-Gang Li; Hohnloser, Stefan H. // Journal of Cardiovascular Pharmacology & Therapeutics;Jun1998, Vol. 3 Issue 2, p185 

    The article discusses therapeutic alternatives for patients with persistent atrial fibrillation. It summarizes the present knowledge on this clinical problem with particular emphasis on issues such as efficacy of antiarrhythmic drugs to prevent recurrent atrial fibrillation, proarrhythmic...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics