Coronary Arteriographic Findings During Early Hours of Acute Myocardial Infarction: Response to Intracoronary Injection of Nitrates

Omote, Shingo; Yasue, Hirofumi; Takizawa, Akinori; Nagao, Masao; Hyon, Hirornitsu; Nishida, Shinichiro; Horie, Minoru
August 1983
Angiology;Aug1983, Vol. 34 Issue 8, p553
Academic Journal
We performed coronary arteriography and gave intracoronary injection of nitrates within 8 hours after the onset of symptoms of acute myocardial infarction in eighteen patients. Improved distal filling or patency of the total occluded coronary artery after intracoronary injection of nitrates occurred in 4 of 18 patients. In one of four patients the first intracoronary nitrates injection failed to release the initial total occlusion, but after intracoronary Urokinase administration, the second nitrates injection succeeded to dilate the completely occluded coronary artery. Coronary arteriography was again performed in sixteen patients in the chronic stage (4-15 weeks after the onset of acute myocardial infarction) and ergonovine malaete was injected intravenously in seven patients. Focal spasm was induced by ergonovine injection in three patients in one of whom intracoronary nitrates failed to release the complete obstruction in the acute stage. We conclude that coronary spasm as well as intracoronary thrombosis plays an important role in the production of acute myocardial infarction.


Related Articles

  • Elevated levels of procoagulant microparticles in a patient with myocardial infarction, antiphospholipid antibodies and multifocal cardiac thrombosis. Morel, O.; Jesel, L.; Freyssinet, J. M.; Toti, F. // Thrombosis Journal;2005, Vol. 3, p15 

    Circulating procoagulant microparticles (MP) are pathogenic markers of enhanced coagulability associated to a variety of disorders and released from stimulated vascular cells. When derived from endothelial cells, MP were found characteristic of thrombotic propensity in primary antiphospholipid...

  • Pharmacists’ role in preventing stent thrombosis. Alvarez, William // American Journal of Health-System Pharmacy;11/1/2005, Vol. 62 Issue 21, p2239 

    Comments on the review of the paclitaxel drug-eluting stent. Risk of stents for stent thrombosis, which may result in myocardial infarction; Occurrence of stent thrombosis; Role of pharmacists in preventing stent thrombosis.

  • ABSENCE OF FACTOR V LEIDEN (G1691A) MUTATION, Fll G20210A ALLELE IN CORONARY ARTERY DISEASE IN NORTH INDIA. Gupta, N.; Khan, F.; Tripathi, M.; Singh, V.P.; Tewari, S.; Ramesh, V.; Sinha, N.; Agrawal, S. // Indian Journal of Medical Sciences;Dec2003, Vol. 57 Issue 12, p535 

    BACKGROUND: Interaction between various genetic and environmental factors is associated with coronary artery diseases (CADs). Factor V Leiden mutation (FVL) and FII G202 10A polymorphism are two recently described genetic factors with a propensity towards venous thrombosis, however, with a...

  • A Rare Presentation of Primary Antiphospholipid Syndrome. Prashanth, Panduranga; Mukhaini, Mohammed; Riyami, Abdulla // Oman Medical Journal;Oct2009, Vol. 24 Issue 4, p300 

    This case presents a young patient with myocardial infarction, in-situ thrombosis of left anterior descending coronary artery and right common-iliac artery due to primary antiphospholipid syndrome. This report discusses the relationship between antiphospholipid antibodies and coronary artery...

  • Three vs Twelve Months of Dual Antiplatelet Therapy After Zotarolirnus-Eluting Stents. Feres, Fausto; Costa, Ricardo A.; Abizaid, Alexandre; Leon, Martin B.; Marin-Neto, J. Antônio; Botelho, Roberto V.; King III, Spencer B.; Negoita, Manuela; Minglei Liu; de Paula, J. Eduardo T.; Mangione, José A.; Meireles, George X.; Castello Jr, Hélio J.; Nicolela Jr, Eduardo L.; Perin, Marco A.; Devito, Fernando S.; Labrunie, André; Salvadori Jr, Décio; Gusmão, Marcos; Staico, Rodolfo // JAMA: Journal of the American Medical Association;12/18/2013, Vol. 310 Issue 23, p2510 

    IMPORTANCE The current recommendation is for at least 12 months of dual antiplatelet therapy after implantation of a drug-eluting stent. However, the optimal duration of dual antiplatelet therapy with specific types of drug-eluting stents remains unknown. OBJECTIVE To assess the clinical...

  • False Positive Cardiac Troponin Results in Patients Without Acute Myocardial Infarction. Gifford Lum; David E. Solarz; Linda Farney // Laboratory Medicine;Sep2006, Vol. 37 Issue 9, p546 

    Cardiac troponin I (cTnI) and T (cTnT) are highly sensitive and specific biochemical markers for myocardial necrosis and are generally not elevated in cases other than acute myocardial infarction (AMI) and acute coronary syndrome (ACS). However, if the patient's clinical picture for AMI or ACS...

  • mural thrombus. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p521 

    An encyclopedia entry for the term "mural thrombus" is presented. It refers to a thombus or blood clot on the inner wall of a heart chamber. The clot, which usually occurs in the lower chamber, develops on a tissue portion that has been damaged by a myocardial infarction.

  • Unstable Angina Associated with Factor VIII Concentrate Therapy for Hemophilia A. Kopitsky, Robert G.; Geltman, Edward M. // Annals of Internal Medicine;Aug86, Vol. 105 Issue 2, p215 

    Describes the medical case of severe unstable angina associated with the use of factor VIII concentrate therapy in a patient with classic hemophilia. Importance of intracoronary thrombosis in the pathophysiology of acute transmural myocardial infarction; Findings of an electrocardiogram and...

  • Stress/Rest Myocardial Perfusion SPET in Evaluation of the Hemodynamic Significance of a Fistula Between the Anterior Descending Branch of the Left Coronary and the Left Pulmonary Arteries. Rubini, Giuseppe; Bovenzi, Francesco; DiGiovine, Giuseppe; D'Agostino, Carlo // Angiology;Jan1998, Vol. 49 Issue 1, p55 

    This paper describes the use of Stress/Rest Tc-99m Sestamibi (MIBI) Single Photon Emission Tomography (SPET) to evaluate the hemodynamic significance of an unusual fistula between the descending anterior branch of the left coronary artery and the left pulmonary artery. Coronary arteriography in...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics