TITLE

THE COMPARATIVE SENSITIVITY OF ISOLATED CORONARY AND. SYSTEMIC VESSELS TO VASOMOTOR AGENTS

AUTHOR(S)
Oppelt, W. W.; Ederstrom, H. E.
PUB. DATE
June 1959
SOURCE
Angiology;Jun1959, Vol. 10 Issue 3, p153
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Coronary and sytemic arteries and veins were removed from fresh beef and dog hearts and prepared in the form of strips for studies in vitro. Strips from systemic arteries and vein, contracted with epinephrine and norepinephrine, whereas those from coronary arteries relaxed. Coronary vein strips contracted in response to these amines. The coronary arteries of the dog differed from those of beef in that the circumflex strips constricted, but those from the anterior descendens relaxed m the presence of the same vasomotor agents. Acetylcholine, serotonin and histamine contracted coronary and systemic arteries and veins. Hypoxia, or a carbon dioxide excess in the bath solution, caused relaxation of coronary arteries but did not affect the veins. In general, coronary vessel preparations were slow and unresponsive in comparison to those from systemic vessels when subjected to the same vasomotor agents. Coronary veins were only slightly responsive to the vasomotor agents used. A study of histologic preparations of the vessels used gave, partial explanation of the results. The amount of smooth muscle present correlated quite well with the magnitude of the response obtained but not with the direction of the response.
ACCESSION #
16388694

 

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