TITLE

INTRAVENOUS ADMINISTRATION OF FIBRINOLYSIN: ITS SYSTEMIC TOXICITY AND EFFECT UPON COMPONENTS OF THE COAGULATION MECHANISM

AUTHOR(S)
Moser, Kenneth M.
PUB. DATE
August 1959
SOURCE
Angiology;Aug1959 Part 2, Vol. 10 Issue 4, p253
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
1. In the doses used, the toxic potential of fibrinolysin is limited primarily to temperature elevation. In the absence of prophylactic medication, a febrile reaction occurred in 44.4 per cent of the patients, and could be correlated only with the presence of extensive thrombotic material. 2. Changes in coagulation factors and parameters were minimal at the dosage levels used, with fibrinogen being affected to the greatest extent. The changes were not of sufficient degree to impair the integrity of the coagulative mechanism. No hemorrhagic phenomena occurred in any patients, including 29 who were simultaneously' receiving anticoagulant drugs. 3. Plasma fibrinolytic activity was significantly enhanced at all dosage levels, with degree and duration of activity being dependent upon dosage.
ACCESSION #
16388354

 

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