Reisman Jr., Edward E.
February 1963
Angiology;Feb1963, Vol. 14 Issue 2, p59
Academic Journal
Trichlormethiazide, 2 or 4 mg, or trichlormethiazide, 2 or 4 mg with reserpine, 0.1 mg, was administered once or twice daily to 40 patients with edema. Most patients who received the diuretic alone had congestive heart disease. The patients who received the compound had essential hypertension or hypertension in association with other edema-producing diseases. A few patients with edema of unknown etiology, primary hepatic or renal disease, postoperative edema, or premenstrual tension also were treated with these drugs. The diuretic response was excellent or good in 33 patients and those with hypertension usually also showed gradual reduction of blood pressure as a consequence of diuresis. There were no instances of hypotension or other significant clinical side effects and no evidence of electrolyte disturbance. The new drug compares favorably with others in its class. Apparently an excellent diuretic response can be achieved in most patients who receive 4 mg of trichlormethiazide twice daily. In combination with reserpine, the drug produces a gradual and sustained antihypertensive effect.


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