TITLE

THE EFFECTS OF PENTAERYTHRITOL TETRANITRATE (PETN) ON ATRIOVENTRICULAR CONDUCTION FOLLOWING ACUTE LIGATION OF THE ANTERIOR SEPTAL ARTERY IN DOGS

AUTHOR(S)
Schechter, Frederick G.
PUB. DATE
June 1967
SOURCE
Angiology;Jun1967, Vol. 18 Issue 6, p394
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Anterior septal artery ligation was performed on 1(X) healthy dogs in which normal sinus rhythm was present preoperatively. The effects of sustained-action pentaerythritol tetranitrate (PETN) administered orally, beginning before and beginning after ligation, were determined in animals developing electrocardiographic evidence of atrioventricular conduction disturbances (partial and complete A-V block, A-V dissociation, A-V nodal rhythm, and idioventricular rhythm) by one day post-ligation and who survived the full eight-day experimental period. These effects were compared with those obtained in a control group of animals which did not receive PETN. Administration of PETN beginning on the first day post-ligation (post-operative-PETN group), and after the development of the arrhythmias, resulted in no significant change in the course of recovery from the arrhythmias. Administration of PETN beginning two days prior to anterior septal artery ligation (preoperative-PETN group) demonstrated: (1) No effect on the incidence of development of arrhythmias by the first day post-ligation. (2) No effect on total per cent recovery from arrhythmias from the fourth to eighth days post-ligation. (3) A statistically significantly increase in the cumulative per cent recovery from arrhythmias by the second day post-ligation when compared to those animals not receiving PETN preoperatively.
ACCESSION #
16388130

 

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