Holti, G.
January 1978
Angiology;Jan1978, Vol. 29 Issue 1, p89
Academic Journal
The article focuses on the experimentally controlled evaluation of vasoactive drugs in digital ischemia. The objective assessment of any allegedly vasoactive drug must be based upon methods which demonstrate clearly whether or not it can abolish or diminish the effect of vasoconstrictor stimuli, i.e., it must imitate under controlled experimental conditions the natural environmental conditions under which the drug would be therapeutically beneficial. Any investigation of this type must be based upon the null hypothesis that there is no difference between the drug under investigation, in its recommended dose, and a placebo, as determined by objective and subjective assessments in patients with primary and secondary Raynaud's phenomenon and with other -cold-sensitive disorders.


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