New Approaches in the Therapy of the Peripheral Vascular Ulcer

Sawyer, Philip N.; Sophie, Z.; Dowbak, G.; Cohen, L.; Feller, J.
September 1978
Angiology;Sep1978, Vol. 29 Issue 9, p666
Academic Journal
The article focuses on new approaches in the therapy of the peripheral vascular ulcer. According to the authors, conservative therapy for venous and other skin ulcers includes cleaning, debriding, or anything short of the placement of a pedicle or complete coverage with skin, or some other physiologic dressing which induces the growth of epithelium. This approach is often ineffective. The newest addition to the art of the surgeon attempting to heal these ulcers is Debrisan. It is an interesting ultralong chain polysaccharide derivative of dextran. The hygroscopic effect dries out the interstices between fibroblasts and the other tissues generated to heal the ulcer. When it effectively does this, the fibroblasts in the base of the wound have been shown to replicate at an increasingly rapid rate so that wound healing occurs quickly. It has long been suggested that dehydration of the fibroblast interstices leads to a rapid growth rate with good healing and effective epithelial coverage.


Related Articles

  • Wound Healing Effects of Debrisan on Varicose, Postoperative, Decubitus, and Sickle-Cell Ulcers in Man. Sawyer, P. N.; Haque, S.; Reddy, K.; Sophie, Z.; Feller, J. // Vascular Surgery;Jul/Aug1979, Vol. 13 Issue 4, p251 

    Presents evidences of the fibroplastic effects of Debrisan microspherules or beads on the treatment of open wounds including cutaneous, decubitus and varicose ulcers. Etiology of ulcers; Evaluation of patients; Effect of therapy on the various evaluating criteria.

  • Hyperbaric Oxygen Therapy in Chronic Vascular Wound Management. Wattel, F.; Mathieu, D.; Coget, J-M; Billard, V. // Angiology;Jan1990, Vol. 41 Issue 1, p59 

    Many nonhealing tissues are hypoxic, with oxygen tensions frequently ranging from S to 15 mmHg. In such an environment, the normal wound healing sequence is disrupted or halted and phagocytic killing activity depressed. So the adjunctive use of hyperbaric oxygen (HBO), based on physiologic data...

  • conservative treatment.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p512 

    A definition of the term "conservative treatment," which refers to organ preservation in surgery, is presented.

  • CASE REPORT OF COLD SENSITIVITY WITH COLD HEMAGGLUTININS. Kramer, David W.; Perilstein, Paul K. // Angiology;Aug1951, Vol. 2 Issue 4, p283 

    Cold sensitivity is not a frequent occurrence among vascular disorders. The causes of this unusual condition are not fully understood. The question of allergy is a significant factor. However, the feeling is that it is not a primary form of allergy, but rather a tendency to exhibit a...

  • Analysis of the mechanical parameters of human brain aneurysm. Tóth, Brigitta K.; Raffai, Gábor; Bojtár, Imre // Acta of Bioengineering & Biomechanics;2005, Vol. 7 Issue 1, p3 

    Cardiovascular disease is one of the most frequent reasons of mortality in the western word. Nowadays the mechanical properties of biological soft tissues were treated from a continuum mechanical perspective. The aim of this article is to investigate the mechanical response of arterial tissue....

  • Two cases of intraocular lymphoma diagnosed by analyses of vitreous and infusion fluid. Matsuoka, Masato; Yoshida, Hideyuki; Kinoshita, Yuichi; Nishimura, Tetsuya // Clinical Ophthalmology;Apr2013, Vol. 7, p691 

    Purpose: Intraocular lymphomas are rare, and they have poor prognosis. Thus, early diagnosis and treatment are needed. A definitive diagnosis of a lymphoma is based on cytological analysis of the intraocular fluids or tissues. We report two cases of intraocular lymphoma diagnosed by the analyses...

  • Transoral Robotic Surgery (TORS) in Laryngeal and Hypopharyngeal Cancer. Young Min Park; Woo Jung Lee; Jeong Gwon Lee; Won Sang Lee; Eun Chang Choi; Sa Myung Chung; Se-Heon Kim // Journal of Laparoendoscopic & Advanced Surgical Techniques;Jun2009, Vol. 19 Issue 3, p361 

    Objectives: The current trend in managing laryngeal and hypopharyngeal cancer is to perform organ preservation therapy, which improves quality of life and decreases treatment-related morbidity. Transoral robotic surgery (TORS) can overcome the limit of “line of sight” often met in...

  • Endoscopic Dissection of Incompetent Perforating Veins in the Treatment of Chronic Venous Leg Ulcers. Wolters, Ulrich; Schmitz-Rixen, Thomas; Erasmi, Heide; Lynch, John // Vascular Surgery;Nov/Dec1996, Vol. 30 Issue 6, p481 

    The role of incompetence of calf perforating veins in chronic venous ulcer is currently becoming better defined. Because the traditional Dodd's and Linton's subfascial surgical eradication is often too traumatic to the compromised skin, the endoscopic subfascial discission of perforating veins...

  • SIX YEARS OF PRESSURE-GRADIENT THERAPY. Beninson, Joseph // Angiology;Jan1961, Vol. 12 Issue 1, p38 

    Recalls the author's experience in applying pressure-gradient therapy for leg ulcers. Superiority of the new method over other known therapies for the disease; Citation of a case in which a patient was successfully treated with the method; Emphasis on the importance of maintaining the healed...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics