TITLE

New Approaches in the Therapy of the Peripheral Vascular Ulcer

AUTHOR(S)
Sawyer, Philip N.; Sophie, Z.; Dowbak, G.; Cohen, L.; Feller, J.
PUB. DATE
September 1978
SOURCE
Angiology;Sep1978, Vol. 29 Issue 9, p666
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article focuses on new approaches in the therapy of the peripheral vascular ulcer. According to the authors, conservative therapy for venous and other skin ulcers includes cleaning, debriding, or anything short of the placement of a pedicle or complete coverage with skin, or some other physiologic dressing which induces the growth of epithelium. This approach is often ineffective. The newest addition to the art of the surgeon attempting to heal these ulcers is Debrisan. It is an interesting ultralong chain polysaccharide derivative of dextran. The hygroscopic effect dries out the interstices between fibroblasts and the other tissues generated to heal the ulcer. When it effectively does this, the fibroblasts in the base of the wound have been shown to replicate at an increasingly rapid rate so that wound healing occurs quickly. It has long been suggested that dehydration of the fibroblast interstices leads to a rapid growth rate with good healing and effective epithelial coverage.
ACCESSION #
16386141

 

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