Achievement of pregnancy three times in the same patient during luteal GnRH agonist administration

Papanikolaou, Evangelos G.; Platteau, Peter; Albano, Carola; Kolibianakis, Efstratios; Devroey, Paul
March 2005
Reproductive BioMedicine Online (Reproductive Healthcare Limited;Mar2005, Vol. 10 Issue 3, p347
Academic Journal
Gonadotrophin-releasing hormone agonist (GnRHa) administration from the mid-luteal phase onwards is considered the gold standard of ovarian stimulation for IVF treatment. It might, however, coincide with an implanting spontaneous pregnancy. Concerns have therefore been raised with regard to the evolution of the resulting pregnancies and long-term outcome of the children born. The current case report describes the achievement of three pregnancies in the same patient during luteal administration of GnRHa. One pregnancy ended in spontaneous abortion and the other two resulted in the delivery of two female infants. The children have so far been followed for 3.5 and 7 years. The physical examination of both children was unremarkable. However, the older child has recently been diagnosed with attention deficit hyperactivity disorder and dyslexia.


Related Articles

  • Use of antagonists in ovarian stimulation protocols. Dal Prato, Luca; Borini, Andrea // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Mar2005, Vol. 10 Issue 3, p330 

    Gonadotrophin-releasing hormone (GnRH) antagonists have been introduced in IVF to prevent premature LH surge. They bind competitively to pituitary receptors and prevent endogenous GnRH from exerting any stimulus on pituitary cells, avoiding the initial 'Hare-up' effect and decreasing...

  • Cessation of gonadotropin-releasing hormone antagonist on triggering day in flexible multiple-dose protocol: A randomized controlled study. Hye Jin Chang; Jung Ryeol Lee; Byung Chul Jee; Chang Suk Suh; Won Don Lee; Seok Hyun Kim // Clinical & Experimental Reproductive Medicine;Jun2013, Vol. 40 Issue 2, p83 

    Objective: To investigate outcomes of stimulated IVF cycles in which GnRH antagonist was omitted on the ovulation triggering day. Methods: A total of 86 women who underwent controlled ovarian hyperstimulation with recombinant FSH and GnRH antagonist flexible multipledose protocols were recruited...

  • Single and Repeated GnRH Agonist Stimulation Tests Compared With Basal Markers of Ovarian Reserve in the Prediction of Outcome in IVF. Hendriks, D. J.; Broekmans, F. J.; Bancsi, L. F. J. M. M.; Looman, C. W. N.; De Jong, F. H.; te Velde, E. R. // Journal of Assisted Reproduction & Genetics;Feb2005, Vol. 22 Issue 2, p65 

    Purpose: To study the value of a single or repeated GnRH agonist stimulation test (GAST) in predicting outcome in IVF compared to basal ovarian reserve tests. Methods: A total of 57 women was included. In a cycle prior to the IVE treatment, on day 3, an antral follicle count (AFC) was performed...

  • Effects of Early Cessation of Triptorelin in In Vitro Fertilization.  // Fertility Weekly;4/18/2005, p2 

    Discusses a study conducted by researchers from the Netherlands, which concludes that early cessation of triptorelin treatment in controlled ovarian hyperstimulation yields similar fertility rates as the conventional long protocol. Efficiency of the early cessation of GnRH-a in controlled...

  • Modified Natural Cycle Using GnRH Antagonist Can Be an Optional Treatment in Poor Responders Undergoing IVF. Elizur, Shai E.; Aslan, Dilek; Shulman, Adrian; Weisz, Boaz; Bider, David; Dor, Jehoshua // Journal of Assisted Reproduction & Genetics;Feb2005, Vol. 22 Issue 2, p75 

    Purpose: To investigate the efficacy of gonadotrophin-releasing hormone (GnRH) antagonist supplementation during natural cycles in poor responders undergoing IVF-ET treatment. Methods: We retrospectively evaluated 540 cycles of 433 suitable patients who were divided by treatment protocol into...

  • A Safer Alternative for IVF Patients Undergoing Ovarian Hyperstimulation.  // Fertility Weekly;4/15/2002, p2 

    The article cites a study conducted by researchers in the Netherlands, published in the February 2002 issue of "The Journal of Clinical Endocrinology and Metabolism," on a safer alternative for in vitro fertilization (IVF) patients undergoing ovarian hyperstimulation. The application of a single...

  • GnRH agonist versus GnRH antagonist in in vitro fertilization and embryo transfer (IVF/ET). Raffaella Depalo, Raffaella; K Jayakrishan, K.; Garruti, Gabriella; Totaro, Ilaria; Panzarino, Mariantonietta; Giorgino, Francesco; Selvaggi, Luigi E. // Reproductive Biology & Endocrinology;2012, Vol. 10 Issue 1, p26 

    Several protocols are actually available for in Vitro Fertilization and Embryo Transfer. The review summarizes the main differences and the clinic characteristics of the protocols in use with GnRH agonists and GnRH antagonists by emphasizing the major outcomes and hormonal changes associated...

  • Balancing selected medication costs with total number of daily injections: a preference analysis of GnRH-agonist and antagonist protocols by IVF patients. Sills, E. Scott; Collins, Gary S.; Salem, Shala A.; Jones, Christopher A.; Peck, Alison C.; Salem, Rifaat D. // Reproductive Biology & Endocrinology;2012, Vol. 10 Issue 1, p67 

    Background: During in vitro fertilization (IVF), fertility patients are expected to self-administer many injections as part of this treatment. While newer medications have been developed to substantially reduce the number of these injections, such agents are typically much more expensive....

  • The effect of oral contraceptive pill for cycle scheduling prior to GnRH-antagonist protocol on IVF cycle parameters and pregnancy outcome. Pinkas, Haim; Sapir, Onit; Avrech, Ori M.; Ben-Haroush, Avi; Ashkenzi, Jacob; Fisch, Benjamin; Farhi, Jacob // Journal of Assisted Reproduction & Genetics;Jan2008, Vol. 25 Issue 1, p29 

    Objective To evaluate the effect of oral contraceptive pills (OCP) pretreatment on IVF cycle outcome in GnRH-antagonist protocol. Design Retrospective cohort study. Setting Major tertiary university-affiliated center. Patients All patients treated with GnRH antagonist in our IVF unit during the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics