TITLE

Ziprasidone: zealous in the treatment of schizophrenia and schizoaffective disorder

PUB. DATE
April 2003
SOURCE
Drugs & Therapy Perspectives;Apr2003, Vol. 19 Issue 4, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Ziprasidone is a novel atypical antipsychotic with a different pharmacological profile from that of other currently available typical and atypical antipsychotics. It is markedly effective, and apparently at least as effective as haloperidol and olanzapine, in patients with acute exacerbations of schizophrenia or schizoaffective disorder. The intramuscular (IM) preparation of ziprasidone has clearly demonstrated its efficacy in patients with psychosis-related agitation; indeed, it appears to be significantly more effective than haloperidol. Generally, ziprasidone is well tolerated: the overall occurrence of adverse events is not markedly different from that in placebo recipients. The drug has limited propensity to cause extrapyramidal adverse effects and is not associated with sustained increases in plasma prolactin levels or marked weight gain. Further comparative studies with new and established antipsychotics are needed to clearly define the roles of the two ziprasidone preparations in the treatment of schizophrenia and related disorders.
ACCESSION #
16384194

 

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