Fishback, David B.; Castor, Louis H.
January 1965
Angiology;Jan1965, Vol. 16 Issue 1, p21
Academic Journal
1. The method is described of performing the fluorescein circulation time determinations in rabbits. In the procedure a normal circulation time of 5 to 6 seconds can be prolonged in most cases by the prior injection of serum from humans with hypertension, thereby demonstrating the presence of vasoconstrictor substances. 2. Three groups, totaling 163 ambulatory patients with hypertension, were treated with various combinations of antihypertensive drugs. 3. Mebutamate alone was effective in 75 per cent of the cases treated; these wore chiefly mild hypertension. Drowsiness was the most prominent side effect. 4. Mebutamate and hydrochlorothiazide was effective in about 90 per cent, of the cases, with side effects chiefly those due to thiazides. 5. Reserpine and hydrochlorothiazide was effective in about 90 per cent of the cases. The side effects noted wore due to reserpine and thiazides. 6. Fifty-three patients with mild to moderately severe essential hypertension wore treated in our office, with a combination of polythiazide and reserpine for an average period of twelve months. The combination produced good to excellent decrease in blood pressure in 51 of the 53 patients. In 3 cases discontinuation was required because of side effects. Side effects are discussed. Usually they were mild. Prevention and control of such untoward manifestations are described. 7. It is the opinion of the investigators that all these combinations constitute an effective relatively safe office treatment of essential hypertension. 8. In cases of failure to reduce the blood pressure with the above; the addition of guanethidine 10 mg to 25 mg once daily helped to reduce the hypertension. 9. Prior to and during treatment with thiazides, it is essential that blood sugar, urea nitrogen, uric acid and potassium be done. The addition of potassium by mouth helps to prevent hypopotassemia.


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