TITLE

ELECTRON MICROSCOPIC STUDIES ON THE MORPHOGENESIS OF FIBRINOID DEGENERATION IN THE MESENTERIC ARTERIES OF HYPERTENSIVE RATS

AUTHOR(S)
Ooneda, Genju; Ooyama, Yasuo; Matsuyama, Kenji; Takatama, Masamitsu; Yoshida, Yoji; Sekiguchi, Morie; Arai, Ikuo
PUB. DATE
January 1965
SOURCE
Angiology;Jan1965, Vol. 16 Issue 1, p8
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
With the object of elucidating the nature and morphogenesis of fibrinoid degeneration of arterial walls, the mesenteric arteries of hypertensive rats with the bilaterally constricted renal arteries were examined in thin sections by electron microscopy. Fibrinoid substance in the intima of these arteries was seen as an aggregate of electron-dense rod-shaped or massive substances, which were not homogoneous, but showed a stripe-pattern, resulting from parallel arrangement of dense threadlike substances. These latter showed regular cross-striations with a period of about 230 �, corresponding with the periodic cross-striations of fibrin. As for the morphogenesis of fibrinoid degeneration, it is considered that a large amount of blood plasma protein, especially fibrinogen, would "insudate" into the subendothelial layer, first by increased pinocytosis, that is, through the canalicular .system of the endothelial cells, and afterwards through the widely opened spaces betweeen the adjacent endothelial cells. There they are polymerized and fused to form fibrinoid substance.
ACCESSION #
16378098

 

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