TITLE

THROMBOLYTIC THERAPY WITH LOCAL PERFUSIONS OF CA-7 (FIBRINOLYTIC ENZYME FROM ASPERGILLUS ORYZAE) IN THE DOG

AUTHOR(S)
Roschlau, Walter H.E.; Fisher, Albert M.
PUB. DATE
September 1966
SOURCE
Angiology;Sep1966, Vol. 17 Issue 9, p670
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The prompt lysis of intravenous and intra-arterial occluding thrombi with local perfusions of non-toxic of CA-7 (fibrinolytic enzyme from Aspergillus oryzae) in the dog is described. The action of blood inhibitors is demonstrated in comparative experiments with injections of CA-7 into thrombosed vessel segments in contact with and in the absence of circulating blood. Slight enzymatic attack on the vessel wall in the absence of inhibitors is shown, as is a pronounced thromboplastin-like activity of small CA-7 doses in the presence of blood. The value of heparin anticoagulation to overcome clotting complications during perfusions with small doses of CA-7 is discussed.
ACCESSION #
16378080

 

Related Articles

  • AN EXPERIMENTAL METHOD FOR QUANTITATIVE EVALUATION OF THROMBOLYSIS: EFFECT OF CA-7, A PROTEASE FROM ASPERGILLUS ORYZAE. Giering, John E.; Truant, Aldo P. // Angiology;Sep1966, Vol. 17 Issue 9, p661 

    A quantitative method is described which is based upon the insertion into the external jugular vein of a preformed, weighed blood clot formed and retracted around a special framework. The frame firmly supports and confines the clot in a fixed position within the vein without completely impeding...

  • Guidelines advise on thrombotic events in urology. Tennant, Scott // Urology Times;1/1/2005, Vol. 33 Issue 1, p4 

    Reports on the American College of Chest Physicians' "Guidelines on Antithrombotic and Thrombolytic Therapy". Risk factors for venous thromboembolism in urologic surgery patients; Mechanical thromboprophylaxis modalities; Comparison between mechanical methods of prophylaxis and anticoagulant...

  • CORONARY ARTERIAL AND OTHER INTRAVASCULAR THROMBOSES TREATED WITH FIBRINOLYSIN. Mazel, M. S.; Bolton, Houck E.; Stern, Joel R.; Riera, Rogelio; Cabral, Hector // Angiology;Feb1963, Vol. 14 Issue 2, p88 

    Investigates the efficacy of fibrinolytic agents for the treatment of intravascular thromboses. Accomplishment of cerebral embolization by cannulation of the carotid artery; Doubts on the actual amount of fibrinolysin which the brain can tolerate by perfusion of a carotid artery; Safety profile...

  • SYSTEMIC TOXICITY OF CA-7 (FIBRINOLYTIC ENZYME FROM ASPERGILLUS ORYZAE) IN THE DOG. Roschlau, Walter H. E. // Angiology;Nov1966, Vol. 17 Issue 11, p882 

    The toxic effects of systemic thrombolytic doses of CA-7 (fibrinolytic enzyme from Aspergillus oryzae) in 36 dogs are summarized. The more important of these are transient hypocoagulability of the blood, transient hypotension, reversible hemoconcentration, reversible liver involvement and...

  • Differential Regulation of Matrix Metalloproteinase-9 and Tissue Plasminogen Activator Activity by the Cyclic-AMP System in Lipopolysaccharide-stimulated Rat Primary Astrocytes. Soon Lee; Hee Kim; Woo Lee; So Joo; Se-Jin Jeon; Ji Kim; Seol-Heui Han; Jongmin Lee; Seung Park; Jae Cheong; Won-Ki Kim; Kwang Ko; Chan Shin // Neurochemical Research;Nov2008, Vol. 33 Issue 11, p2324 

    Abstract  We investigated the effect of the cAMP system on lipopolysaccharide (LPS)-induced changes in the activity of matrix metalloproteinases (MMPs) and tissue plasminogen activator (tPA) in rat primary astrocytes. LPS stimulation increased MMP-9 and decreased tPA activity in rat...

  • Plasminogen-related.  // Encyclopedic Reference of Cancer;2001, p701 

    A definition of the term "plasminogen-related protein" is presented. It refers to a protein that shares structural similarity and evolutionary relationship with plasminogen.

  • A QUANTITATIVE METHOD FOR THE STUDY OF THROMBOLYSIS. Boyles, Paul W.; Meyer, William H. // Angiology;Jul1964, Vol. 15 Issue 7, p326 

    An apparatus is described combining the advantages of in vivo and in vitro methods for the study of clot lysis. This technique permits direct observation of a standard clot in the presence of a dynamic circulation.

  • Multicenter Trials of Treatment for Empyema – After All These Years. Heffner, John E. // New England Journal of Medicine;3/3/2005, Vol. 352 Issue 9, p926 

    The article focuses on the lack of evidence concerning treatment for empyema. As stated, with the absence of high-quality trials, suggestions for managing pleural infections have relied on pathophysiological observations, small studies, and expert opinion. In this context, a multicenter study...

  • Thrombolytic Drugs in Acute Myocardial Infarction. Iqbal, Omer; Messmore, Harry; Hoppensteadt, Debra; Fareed, Jawed; Wehrmacher, William // Clinical & Applied Thrombosis/Hemostasis;Jan2000, Vol. 6 Issue 1, p1 

    Focuses on the role of thrombolytic drugs in the management of patients with acute myocardial infarction. Discussion on the timing and survival benefit of using thrombolytic drugs; Selection criteria for lytic therapy; Description of the three generations of thrombolytic agents.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics